Transcription control by the ENL YEATS domain in acute leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21688
Abstract: Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on… read more here.
Keywords: transcription control; enl; yeats domain; acute leukaemia ... See more keywords
Insights into mammalian transcription control by systematic analysis of ChIP sequencing data
Sign Up to like & getrecommendations! Published in 2018 at "BMC Bioinformatics"
DOI: 10.1186/s12859-018-2377-x
Abstract: BackgroundTranscription regulation is a major controller of gene expression dynamics during development and disease, where transcription factors (TFs) modulate expression of genes through direct or indirect DNA interaction. ChIP sequencing has become the most widely… read more here.
Keywords: transcription control; chip sequencing; sequencing data; chip ... See more keywords