TEFM Enhances Transcription Elongation by Modifying mtRNAP Pausing Dynamics.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.11.004
Abstract: Regulation of transcription elongation is one of the key mechanisms employed to control gene expression. The single-subunit mitochondrial RNA polymerase (mtRNAP) transcribes mitochondrial genes, such as those related to ATP synthesis. We investigated how mitochondrial… read more here.
Keywords: transcription; tefm enhances; elongation; transcription elongation ... See more keywords
Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.09.027
Abstract: The super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC… read more here.
Keywords: cancer; processive transcription; transcription elongation; sec ... See more keywords
Paf1 Has Distinct Roles in Transcription Elongation and Differential Transcript Fate
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cell"
DOI: 10.1016/j.molcel.2017.01.006
Abstract: Summary RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymerase-associated factor 1 (Paf1), but it is not known… read more here.
Keywords: transcript; elongation; transcription elongation; fate ... See more keywords
Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.02.023
Abstract: Spt5 is an essential and conserved factor that functions in transcription and co-transcriptional processes. However, many aspects of the requirement for Spt5 in transcription are poorly understood. We have analyzed the consequences of Spt5 depletion in… read more here.
Keywords: transcription; spt5; sense; transcription elongation ... See more keywords
A Novel Assay for RNA Polymerase I Transcription Elongation Sheds Light on the Evolutionary Divergence of Eukaryotic RNA Polymerases.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b01256
Abstract: Eukaryotic cells express at least three nuclear RNA polymerases (Pols), each with a unique set of gene targets. Though these enzymes are homologous, there are many differences among the Pols. In this study, a novel… read more here.
Keywords: novel assay; elongation; transcription elongation; rate ... See more keywords
Effects of Histone H2B Ubiquitylations and H3K79me3 on Transcription Elongation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00887
Abstract: Post-translational modifications of histone proteins often mediate gene regulation by altering the global and local stability of the nucleosome, the basic gene-packing unit of eukaryotes. We employed semisynthetic approaches to introduce histone H2B ubiquitylations at… read more here.
Keywords: histone h2b; transcription; transcription elongation; h2b ubiquitylations ... See more keywords
Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40960
Abstract: The p53 tumour suppressor regulates the transcription initiation of selected genes by binding to specific DNA sequences at their promoters. Here we report a novel role of p53 in transcription elongation in human cells. Our… read more here.
Keywords: transcription elongation; p53; transcription; elongation blockage ... See more keywords
A code for transcription elongation speed
Sign Up to like & getrecommendations! Published in 2018 at "RNA Biology"
DOI: 10.1080/15476286.2017.1384118
Abstract: ABSTRACT The two major steps of gene expression are transcription and translation. While hundreds of studies regarding the effect of sequence features on the translation elongation process have been published, very few connect sequence features… read more here.
Keywords: transcription; code transcription; elongation; transcription elongation ... See more keywords
GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjac009
Abstract: Alternative splicing (AS) and transcription elongation are vital biological processes, and their dysregulation causes multiple diseases, including tumors. However, the co-regulatory mechanism of AS and transcription elongation in tumors remains unclear. This study demonstrates a… read more here.
Keywords: elongation; transcription elongation; zo1; alternative splicing ... See more keywords
Allosteric couplings upon binding of RfaH to transcription elongation complexes
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac453
Abstract: Abstract In every domain of life, NusG-like proteins bind to the elongating RNA polymerase (RNAP) to support processive RNA synthesis and to couple transcription to ongoing cellular processes. Structures of factor-bound transcription elongation complexes (TECs)… read more here.
Keywords: nusg rfah; transcription; transcription elongation; elongation complexes ... See more keywords
Structural insights into NusG regulating transcription elongation
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1159
Abstract: NusG is an essential transcription factor that plays multiple key regulatory roles in transcription elongation, termination and coupling translation and transcription. The core role of NusG is to enhance transcription elongation and RNA polymerase processivity.… read more here.
Keywords: transcription; insights nusg; rna polymerase; structural insights ... See more keywords