Transcription factor SOX2 contributes to nonalcoholic fatty liver disease development by regulating the expression of the fatty acid transporter CD36
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DOI: 10.1002/1873-3468.14193
Abstract: Nonalcoholic fatty liver disease (NAFLD) can lead to hepatocellular carcinoma (HCC). The level of the transcription factor SOX2 correlates with HCC progression, but its role in fat accumulation remains unclear. Here, a high‐fat diet, with… read more here.
Keywords: fatty liver; cd36; transcription factor; sox2 ... See more keywords
The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding
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DOI: 10.1002/1873-3468.14338
Abstract: The function of the transcription factor BACH1 is regulated by heme binding to multiple Cys‐Pro (CP) motifs within its intrinsically disordered regions. Here, biochemical analyses were conducted to reveal the individual functional roles of the… read more here.
Keywords: cys pro; heme; heme binding; factor bach1 ... See more keywords
Transcription factor Atf1‐dependent degradation of the mitotic cyclin Cdc13 is regulated by multiple factors in Schizosaccharomyces pombe
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DOI: 10.1002/1873-3468.14439
Abstract: The bZIP transcription factor Atf1 is a key player in the transcriptional programme of Schizosaccharomyces pombe cell cycle. It also controls both expression and degradation of mitotic cyclin Cdc13. Temporal regulation of these opposing functions of… read more here.
Keywords: degradation mitotic; mitotic cyclin; factor atf1; schizosaccharomyces pombe ... See more keywords
Transcription factor EB controls both motogenic and mitogenic cell activities
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DOI: 10.1002/1873-3468.14442
Abstract: Transcription factor EB (TFEB) belongs to the microphthalmia family of bHLH‐leucine zipper transcription factors and was first identified as an oncogene in a subset of renal cell carcinomas. In addition to exhibiting oncogenic activity, TFEB… read more here.
Keywords: cell; transcription; factor controls; transcription factor ... See more keywords
The TFAMoplex—Conversion of the Mitochondrial Transcription Factor A into a DNA Transfection Agent
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DOI: 10.1002/advs.202104987
Abstract: Non‐viral gene delivery agents, such as cationic lipids, polymers, and peptides, mainly rely on charge‐based and hydrophobic interactions for the condensation of DNA molecules into nanoparticles. The human protein mitochondrial transcription factor A (TFAM), on… read more here.
Keywords: dna; transfection agent; mitochondrial transcription; transcription factor ... See more keywords
Mutation of a Conserved Alanine Residue in Transcription Factor AraR Leads to Hyperproduction of α-l-Arabinofuranosidases in Penicillium oxalicum.
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DOI: 10.1002/biot.201800643
Abstract: α-l-Arabinofuranosidases are important in the degradation of plant polysaccharides and are used in several industrial processes. Although the use of filamentous fungi for the production of α-l-arabinofuranosidases is widely reported, there are few reports on… read more here.
Keywords: factor arar; transcription factor; production; penicillium oxalicum ... See more keywords
Effects of inactivation of the cyAbrB2 transcription factor together with glycogen synthesis on cellular metabolism and free fatty acid production in the cyanobacterium Synechocystis sp. PCC 6803
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DOI: 10.1002/bit.26842
Abstract: Deletion of the cyAbrB2 (Sll0822) transcription factor in Synechocystis sp. PCC 6803 causes aberrant accumulation of glycogen. We previously tried to redirect the excess carbon stored as glycogen in the cyabrB2‐disrupted (∆ cyabrB2) mutant by… read more here.
Keywords: cyabrb2; pcc 6803; synechocystis pcc; transcription factor ... See more keywords
Protective role of activating transcription factor 3 against neuronal damage in rats with cerebral ischemia
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DOI: 10.1002/brb3.2522
Abstract: The participation of activating transcription factor 3 (ATF3) in transient middle cerebral artery occlusion and reperfusion injury has been reported. However, the precise mechanism of ATF3 in cerebral ischemia is little known so far. Thus,… read more here.
Keywords: cerebral ischemia; protective role; activating transcription; transcription factor ... See more keywords
Ser625 of msn2 transcription factor is indispensable for ethanol tolerance and alcoholic fermentation process
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DOI: 10.1002/btpr.2837
Abstract: The genetic modification of yeast strains can be used as an approach for the improvement of ethanol fermentation. msn2p transcription factor is implicated in yeast stress response and its activation is controlled by protein kinase… read more here.
Keywords: transcription factor; msn2; ethanol tolerance; fermentation ... See more keywords
Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis‐associated cancer
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DOI: 10.1002/cac2.12184
Abstract: Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with inflammation and tumorigenesis. This study aimed to investigate whether mitochondrial transcription factor A (TFAM), a key regulator of… read more here.
Keywords: transcription; initiation progression; mitochondrial transcription; transcription factor ... See more keywords
Asymmetrically Substituted m‐Terphenyl Phosphates Inhibit the Transcription Factor STAT5a
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DOI: 10.1002/cbic.202100603
Abstract: We recently presented Stafia‐1 as the first chemical entity that inhibits the transcription factor STAT5a with selectivity over the highly homologous STAT5b. Stafia‐1, which was identified from a series of symmetrically substituted m‐terphenyl phosphates, binds… read more here.
Keywords: transcription factor; asymmetrically substituted; terphenyl phosphates; factor stat5a ... See more keywords