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   Articles with "transcription initiation" as a keyword



Studying transcription initiation by RNA polymerase with diffusion‐based single‐molecule fluorescence

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recommendations! Published in 2017 at "Protein Science"

DOI: 10.1002/pro.3160

Abstract: Over the past decade, fluorescence‐based single‐molecule studies significantly contributed to characterizing the mechanism of RNA polymerase at different steps in transcription, especially in transcription initiation. Transcription by bacterial DNA‐dependent RNA polymerase is a multistep process… read more here.

Keywords: transcription; transcription initiation; single molecule; rna polymerase ... See more keywords

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.

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recommendations! Published in 2018 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b01225

Abstract: The biological functions of the dual bromodomains of human transcription-initiation-factor TFIID subunit 1 (TAF1(1,2)) remain unknown, although TAF1 has been identified as a potential target for oncology research. Here, we describe the discovery of a… read more here.

Keywords: factor tfiid; transcription initiation; initiation factor; tfiid subunit ... See more keywords

Real-time observation of polymerase-promoter contact remodeling during transcription initiation

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-01041-1

Abstract: Critical contacts made between the RNA polymerase (RNAP) holoenzyme and promoter DNA modulate not only the strength of promoter binding, but also the frequency and timing of promoter escape during transcription. Here, we describe a… read more here.

Keywords: transcription; real time; polymerase; promoter ... See more keywords

The route to transcription initiation determines the mode of transcriptional bursting in E. coli

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-16367-6

Abstract: Transcription is fundamentally noisy, leading to significant heterogeneity across bacterial populations. Noise is often attributed to burstiness, but the underlying mechanisms and their dependence on the mode of promotor regulation remain unclear. Here, we measure… read more here.

Keywords: transcription; route transcription; transcription initiation; regulated via ... See more keywords
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The dynamic landscape of transcription initiation in yeast mitochondria

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-17793-2

Abstract: Controlling efficiency and fidelity in the early stage of mitochondrial DNA transcription is crucial for regulating cellular energy metabolism. Conformational transitions of the transcription initiation complex must be central for such control, but how the… read more here.

Keywords: yeast mitochondria; transcription; initiation; dynamic landscape ... See more keywords

Eukaryotic core promoters and the functional basis of transcription initiation

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recommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"

DOI: 10.1038/s41580-018-0028-8

Abstract: RNA polymerase II (Pol II) core promoters are specialized DNA sequences at transcription start sites of protein-coding and non-coding genes that support the assembly of the transcription machinery and transcription initiation. They enable the highly… read more here.

Keywords: transcription; gene; transcription initiation; core promoters ... See more keywords

Position-dependent function of human sequence-specific transcription factors

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recommendations! Published in 2024 at "Nature"

DOI: 10.1038/s41586-024-07662-z

Abstract: Patterns of transcriptional activity are encoded in our genome through regulatory elements such as promoters or enhancers that, paradoxically, contain similar assortments of sequence-specific transcription factor (TF) binding sites1, 2–3. Knowledge of how these sequence… read more here.

Keywords: transcription initiation; specific transcription; position; sequence ... See more keywords

An SI3-σ arch stabilizes cyanobacteria transcription initiation complex

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2219290120

Abstract: Multi-subunit RNA polymerases (RNAPs) associate with initiation factors (σ in bacteria) to start transcription. The σ factors are responsible for recognizing and unwinding promoter DNA in all bacterial RNAPs. Here, we report two cryo-EM structures… read more here.

Keywords: transcription; transcription initiation; si3 arch; initiation ... See more keywords

Impaired function of rDNA transcription initiation machinery leads to derepression of ribosomal genes with insertions of R2 retrotransposon

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkab1276

Abstract: Abstract Eukaryotic genomes harbor hundreds of rRNA genes, many of which are transcriptionally silent. However, little is known about selective regulation of individual rDNA units. In Drosophila melanogaster, some rDNA repeats contain insertions of the… read more here.

Keywords: insertions retrotransposon; derepression; rdna transcription; rdna units ... See more keywords

Hybrid exons evolved by coupling transcription initiation and splicing at the nucleotide level

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae1251

Abstract: Abstract Exons within transcripts are traditionally classified as first, internal or last exons, each governed by different regulatory mechanisms. We recently described the widespread usage of ‘hybrid’ exons that serve as terminal or internal exons… read more here.

Keywords: initiation splicing; hybrid exons; transcription initiation; internal exons ... See more keywords

Viral reprogramming of host transcription initiation

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae175

Abstract: Abstract Viruses are master remodelers of the host cell environment in support of infection and virus production. For example, viruses typically regulate cell gene expression through modulating canonical cell promoter activity. Here, we show that… read more here.

Keywords: initiation; transcription initiation; host; viral reprogramming ... See more keywords