Topologically switchable and gated transcription machinery
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc01599d
Abstract: Topological barriers control in nature the transcription machinery, thereby perturbing gene expression. Here we introduce synthetically designed DNA templates that include built-in topological barriers for switchable, triggered-controlled transcription of RNA aptamers. This is exemplified with… read more here.
Keywords: transcription; rna; rna aptamer; gated transcription ... See more keywords
Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery
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DOI: 10.3390/ijms21093354
Abstract: Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we review the molecular targets and mechanisms of action of these compounds, framing them within… read more here.
Keywords: transcription; transcription machinery; rna polymerase; general rna ... See more keywords