Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD‐NF‐κB‐NR2F1 nexus
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28749
Abstract: Hepatitis B Virus (HBV) replication has been reported to be restricted by the intrahepatic host restriction factors and antiviral signaling pathways. The intracellular mechanisms underlying the significant viremia difference among different phases of the natural… read more here.
Keywords: higd1a; pnkd nr2f1; hbv; replication ... See more keywords
Transcription-Replication Conflicts: Orientation Matters
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DOI: 10.1016/j.cell.2017.07.040
Abstract: Interference between DNA replication and transcription represents a major source of genomic instability. In this issue of Cell, Lang et al. and Hamperl et al. show that head-on collisions, but not codirectional collisions, impede fork progression in… read more here.
Keywords: orientation matters; transcription replication; replication conflicts; conflicts orientation ... See more keywords
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.11.002
Abstract: The MYCN oncoprotein drives the development of numerous neuroendocrine and pediatric tumors. Here we show that MYCN interacts with the nuclear RNA exosome, a 3'-5' exoribonuclease complex, and recruits the exosome to its target genes.… read more here.
Keywords: transcription replication; rna polymerase; replication conflicts; replication ... See more keywords
LncRNA HOTAIR Modulates Hepatitis B Virus Transcription and Replication by Enhancing SP1 Transcription Factor.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical science"
DOI: 10.1042/cs20200970
Abstract: Hepatitis B virus (HBV) infection remains a global public health problem. Nearly 257 million people worldwide have been infected with HBV, resulting in 887,000 people dying of cirrhosis or liver cancer caused by chronic hepatitis… read more here.
Keywords: hepatitis virus; transcription replication; transcription; hbv ... See more keywords
Structure of a rabies virus polymerase complex from electron cryo-microscopy
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1918809117
Abstract: Significance Rabies virus (RABV) and other viruses with single-segment, negative-sense, RNA genomes have a multi-functional polymerase protein (L) that carries out the various reactions required for transcription and replication. Many of these viruses are serious… read more here.
Keywords: structure; transcription replication; polymerase; microscopy ... See more keywords
A distinct role for recombination repair factors in an early cellular response to transcription–replication conflicts
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa268
Abstract: Abstract Transcription–replication (T–R) conflicts are profound threats to genome integrity. However, whilst much is known about the existence of T–R conflicts, our understanding of the genetic and temporal nature of how cells respond to them… read more here.
Keywords: transcription replication; cellular response; response; repair ... See more keywords
DDX17 helicase promotes resolution of R-loop-mediated transcription–replication conflicts in human cells
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1116
Abstract: Abstract R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid and displaced DNA strand. These structures can halt DNA replication when formed co-transcriptionally in the opposite orientation to replication fork progression. A recent… read more here.
Keywords: ddx17 helicase; loop; transcription; replication ... See more keywords
Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad172
Abstract: Abstract BRCA1 mutations are associated with increased breast and ovarian cancer risk. BRCA1-mutant tumors are high-grade, recurrent, and often become resistant to standard therapies. Herein, we performed a targeted CRISPR-Cas9 screen and identified MEPCE, a… read more here.
Keywords: brca1; excessive transcription; brca1 mutant; replication ... See more keywords
KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.795388
Abstract: Hepatitis B virus (HBV) infection remains a major health problem worldwide. Sufficient maintenance of the HBV covalently closed circular DNA (cccDNA), which serves as a template for HBV transcription, is responsible for the failure of… read more here.
Keywords: transcription replication; transcription; hepatitis virus; hbv ... See more keywords
SIRT2 Promotes HBV Transcription and Replication by Targeting Transcription Factor p53 to Increase the Activities of HBV Enhancers and Promoters
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.836446
Abstract: Chronic hepatitis B (CHB) virus infection is one of the leading causes of cirrhosis and liver cancer. Although the major drugs against CHB including nucleos(t)ide analogs and PEG-interferon can effectively control human hepatitis B virus… read more here.
Keywords: hbv; transcription; hbv transcription; p53 ... See more keywords
Transcription–Replication Coordination
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12010108
Abstract: Transcription and replication are the two most essential processes that a cell does with its DNA: they allow cells to express the genomic content that is required for their functions and to create a perfect… read more here.
Keywords: replication coordination; replication; two processes; transcription replication ... See more keywords