The Role of Signal Transducer and Activator of Transcription 3 (STAT3) and Its Targeted Inhibition in Hematological Malignancies
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DOI: 10.3390/cancers10090327
Abstract: Signal transducer and activator of transcription 3 (STAT3), a member of the STAT protein family, can be phosphorylated by receptor-associated Janus kinases (JAKs) in response to stimulation by cytokines and growth factors. It forms homo-… read more here.
Keywords: transcription; signal transducer; transcription stat3; activator transcription ... See more keywords
Hybridization Approach to Identify Salicylanilides as Inhibitors of Tubulin Polymerization and Signal Transducers and Activators of Transcription 3 (STAT3)
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DOI: 10.3390/ph15070835
Abstract: The superimposition of the X-ray complexes of cyclohexanediones (i.e., TUB015), described by our research group, and nocodazole, within the colchicine binding site of tubulin provided an almost perfect overlap of both ligands. This structural information… read more here.
Keywords: activators transcription; transducers activators; signal transducers; transcription stat3 ... See more keywords