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   Articles with "transcription termination" as a keyword



Fast Translation within the First 45 Codons Decreases mRNA Stability and Increases Premature Transcription Termination in E. coli.

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recommendations! Published in 2019 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.01.026

Abstract: We show here that the specific use of fast or slowly translated codons in the early coding region of a gene may influence both the mRNA stability and premature transcription termination. We first inserted a… read more here.

Keywords: translation; mrna stability; termination; transcription termination ... See more keywords

Vibrio cholerae YaeO is a structural homologue of RNA chaperone Hfq that inhibits Rho-dependent transcription termination by dissociating its hexameric state.

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recommendations! Published in 2019 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2019.09.019

Abstract: Rho-dependent transcription termination is a well conserved process in bacteria. The Psu and YaeO proteins are the two established inhibitors of the ATP-dependent RNA helicase Rho protein of E. coli. Here we show a detailed… read more here.

Keywords: transcription termination; rna; cholerae yaeo; dependent transcription ... See more keywords

Cell-Cycle Modulation of Transcription Termination Factor Sen1

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recommendations! Published in 2018 at "Molecular Cell"

DOI: 10.1016/j.molcel.2018.03.010

Abstract: Summary Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are surprisingly low compared with Nrd1 and Nab3, raising questions regarding how… read more here.

Keywords: transcription termination; sen1; termination; cell cycle ... See more keywords

Purification and Structural Characterization of N-Terminal 190 Amino Acid Deleted Essential Mammalian Protein; Transcription Termination Factor 1

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c05603

Abstract: The mammalian transcription termination factor 1 (TTF1) is an essential protein that plays diverse cellular physiological functions like transcription regulation (both initiation and termination), replication fork blockage, chromatin remodeling, and DNA damage repair. Hence, understanding… read more here.

Keywords: transcription termination; spectroscopy; termination factor; protein ... See more keywords

Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14731

Abstract: Rifampicin, which inhibits bacterial RNA polymerase, provides one of the most effective treatments for tuberculosis. Inhibition of the transcription termination factor Rho is used to treat some bacterial infections, but its importance varies across bacteria.… read more here.

Keywords: transcription; transcription termination; tuberculosis; termination factor ... See more keywords

Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae

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recommendations! Published in 2023 at "RNA Biology"

DOI: 10.1080/15476286.2023.2192552

Abstract: ABSTRACT Telomeres are terminal structures that define the ends of linear chromosomes. They harbour specialized ribonucleoprotein complexes which play a major role in genome integrity by preventing unscheduled DNA damage repair events. Genes located adjacent… read more here.

Keywords: rat1; transcription termination; termination complex; telomeric transcripts ... See more keywords

Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination.

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recommendations! Published in 2023 at "Nucleic acids research"

DOI: 10.1093/nar/gkad394

Abstract: The genomes of kinetoplastids are organized into polycistronic transcription units that are flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous work established a role of base J in promoting RNA polymerase II (Pol… read more here.

Keywords: transcription termination; role; transcription; pp1 ... See more keywords

Mutagenesis studies suggest a mechanism for influenza polymerase stalling during polyadenylation

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae1225

Abstract: Abstract Influenza polymerase (FluPol) carries out both viral transcription and replication using the same viral genome segment as a template to yield distinct end products. However, it remains largely unclear how FluPol synthesizes transcripts containing… read more here.

Keywords: studies suggest; termination; transcription termination; transcription ... See more keywords

A transcription termination mechanism for maintaining homogeneous protein expression

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkaf1199

Abstract: Abstract Premature transcription termination is a critical mechanism for repressing harmful, unproductive transcription. In Saccharomyces cerevisiae, premature termination by the Nrd1–Nab3–Sen1 (NNS) complex also triggers decay of mRNAs induced to counteract stress. However, why mRNAs… read more here.

Keywords: termination; transcription termination; cell; mechanism ... See more keywords

Computational prediction of regulatory, premature transcription termination in bacteria

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkw749

Abstract: A common strategy for regulation of gene expression in bacteria is conditional transcription termination. This strategy is frequently employed by 5′UTR cis-acting RNA elements (riboregulators), including riboswitches and attenuators. Such riboregulators can assume two mutually… read more here.

Keywords: transcription termination; regulatory premature; computational prediction; prediction regulatory ... See more keywords

Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx434

Abstract: Abstract Riboswitches are regulatory elements that control gene expression by altering RNA structure upon the binding of specific metabolites. Although Bacillus subtilis riboswitches have been shown to control premature transcription termination, less is known about… read more here.

Keywords: control; rho dependent; transcription termination;