Fast Translation within the First 45 Codons Decreases mRNA Stability and Increases Premature Transcription Termination in E. coli.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.01.026
Abstract: We show here that the specific use of fast or slowly translated codons in the early coding region of a gene may influence both the mRNA stability and premature transcription termination. We first inserted a… read more here.
Keywords: translation; mrna stability; termination; transcription termination ... See more keywords
Vibrio cholerae YaeO is a structural homologue of RNA chaperone Hfq that inhibits Rho-dependent transcription termination by dissociating its hexameric state.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.019
Abstract: Rho-dependent transcription termination is a well conserved process in bacteria. The Psu and YaeO proteins are the two established inhibitors of the ATP-dependent RNA helicase Rho protein of E. coli. Here we show a detailed… read more here.
Keywords: transcription termination; rna; cholerae yaeo; dependent transcription ... See more keywords
Cell-Cycle Modulation of Transcription Termination Factor Sen1
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DOI: 10.1016/j.molcel.2018.03.010
Abstract: Summary Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are surprisingly low compared with Nrd1 and Nab3, raising questions regarding how… read more here.
Keywords: transcription termination; sen1; termination; cell cycle ... See more keywords
Purification and Structural Characterization of N-Terminal 190 Amino Acid Deleted Essential Mammalian Protein; Transcription Termination Factor 1
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DOI: 10.1021/acsomega.2c05603
Abstract: The mammalian transcription termination factor 1 (TTF1) is an essential protein that plays diverse cellular physiological functions like transcription regulation (both initiation and termination), replication fork blockage, chromatin remodeling, and DNA damage repair. Hence, understanding… read more here.
Keywords: transcription termination; spectroscopy; termination factor; protein ... See more keywords
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death
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DOI: 10.1038/ncomms14731
Abstract: Rifampicin, which inhibits bacterial RNA polymerase, provides one of the most effective treatments for tuberculosis. Inhibition of the transcription termination factor Rho is used to treat some bacterial infections, but its importance varies across bacteria.… read more here.
Keywords: transcription; transcription termination; tuberculosis; termination factor ... See more keywords
Transcription termination complex, Rtt103-Rai1-Rat1, regulates sub-telomeric transcripts in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2023 at "RNA Biology"
DOI: 10.1080/15476286.2023.2192552
Abstract: ABSTRACT Telomeres are terminal structures that define the ends of linear chromosomes. They harbour specialized ribonucleoprotein complexes which play a major role in genome integrity by preventing unscheduled DNA damage repair events. Genes located adjacent… read more here.
Keywords: rat1; transcription termination; termination complex; telomeric transcripts ... See more keywords
Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad394
Abstract: The genomes of kinetoplastids are organized into polycistronic transcription units that are flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous work established a role of base J in promoting RNA polymerase II (Pol… read more here.
Keywords: transcription termination; role; transcription; pp1 ... See more keywords
Computational prediction of regulatory, premature transcription termination in bacteria
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DOI: 10.1093/nar/gkw749
Abstract: A common strategy for regulation of gene expression in bacteria is conditional transcription termination. This strategy is frequently employed by 5′UTR cis-acting RNA elements (riboregulators), including riboswitches and attenuators. Such riboregulators can assume two mutually… read more here.
Keywords: transcription termination; regulatory premature; computational prediction; prediction regulatory ... See more keywords
Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation
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DOI: 10.1093/nar/gkx434
Abstract: Abstract Riboswitches are regulatory elements that control gene expression by altering RNA structure upon the binding of specific metabolites. Although Bacillus subtilis riboswitches have been shown to control premature transcription termination, less is known about… read more here.
Keywords: control; rho dependent; transcription termination;
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1101/2022.08.25.505353
Abstract: Prolonged pausing of the transcription machinery may lead to the formation of three-stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the nascent RNA with the template DNA. Unscheduled persistence of R-loops… read more here.
Keywords: transcription termination; setx; transcription; bona fide ... See more keywords
Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.09.02.506315
Abstract: Transcription termination is an essential step in transcription by RNA polymerase (RNAP) and crucial for gene regulation. For many bacterial genes, transcription termination is mediated by the ATP-dependent RNA translocase/helicase Rho, which causes the dissociation… read more here.
Keywords: transcription termination; rna polymerase; rho; termination ... See more keywords