CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00931-5
Abstract: Chemotherapy-induced peripheral neuropathic pain (CIPNP) often occurs in cancer patients treated with antineoplastic drugs. Therapeutic management of CIPNP is very limited, at least in part due to the largely unknown mechanisms that underlie CIPNP genesis.… read more here.
Keywords: dnmt3a; paclitaxel induced; drg; neurons creb ... See more keywords
Transcriptional activation of the MICA gene with an engineered CRISPR-Cas9 system.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.076
Abstract: Major histocompatibility complex class I polypeptide-related sequence A (MICA) is a prototypical NKG2D ligand. Because immune cells, such as natural killer (NK) cells, recognize virally infected or transformed cells and eliminate them through the interaction… read more here.
Keywords: activation mica; mica; mica gene; transcriptional activation ... See more keywords
Transcriptional activation of NANOG by YBX1 promotes lung cancer stem-like properties and metastasis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.033
Abstract: Aberrant overexpression of the transcription/translation factor Y-box-binding protein-1 (YBX1) is associated with non-small cell lung cancer (NSCLC) aggressiveness. Cancer stem cells (CSCs) contribute to the tumorigenesis and metastasis of NSCLC. Hitherto, the mechanism by which… read more here.
Keywords: cancer stem; ybx1; lung cancer; cancer ... See more keywords
Transcriptional activation of ANO1 promotes gastric cancer progression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.001
Abstract: The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. The GC-related molecular mechanisms underlying invasion and metastasis are not well understood. In this study, we investigated the functional role… read more here.
Keywords: gastric cancer; metastasis; ano1; progression ... See more keywords
Phosphorylation of RAV1/2 by KIN10 is essential for transcriptional activation of CAT6/7, which underlies oxidative stress response in cassava.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110119
Abstract: Related to ABI3/VP1 (RAV) transcription factors have important roles in plant stress responses; however, it is unclear whether RAVs regulates oxidative stress response in cassava (Manihot esculenta). In this study, we report that MeRAV1/2 positively… read more here.
Keywords: stress; stress response; transcriptional activation; oxidative stress ... See more keywords
A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain.
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.01.015
Abstract: Transcriptional activation domains are essential for gene regulation, but their intrinsic disorder and low primary sequence conservation have made it difficult to identify the amino acid composition features that underlie their activity. Here, we describe… read more here.
Keywords: activation domain; high throughput; activation; transcriptional activation ... See more keywords
CRISPR/dCas9-RpoD-Mediated Simultaneous Transcriptional Activation and Repression in Shewanella oneidensis MR-1.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00149
Abstract: Extracellular electron transfer (EET) of electroactive microorganisms (EAMs) is the dominating factor for versatile applications of bio-electrochemical systems. Shewanella oneidensis MR-1 is one of the model EAMs for the study of EET, which is associated… read more here.
Keywords: shewanella oneidensis; transcriptional activation; repression; rpod ... See more keywords
A TGFβ-PRMT5-MEP50 Axis Regulates Cancer Cell Invasion through Histone H3 and H4 Arginine Methylation Coupled Transcriptional Activation and Repression
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.205
Abstract: Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77 catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is elevated in cancer cells and its expression is highly correlated with poor prognosis in many human… read more here.
Keywords: methylation; prmt5 mep50; cancer; histone ... See more keywords
Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Oral Science"
DOI: 10.1038/s41368-018-0029-7
Abstract: The interplay between mechanoresponses and a broad range of fundamental biological processes, such as cell cycle progression, growth and differentiation, has been extensively investigated. However, metabolic regulation in mechanobiology remains largely unexplored. Here, we identified… read more here.
Keywords: glucose transporter; tooth movement; orthodontic tooth; glut1 ... See more keywords
A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad086
Abstract: Topoisomerases are required to release topological stress generated by RNA polymerase II (RNAPII) during transcription. Here, we show that in response to starvation, the complex of topoisomerase 3b (TOP3B) and TDRD3 can enhance not only… read more here.
Keywords: top3b; transcriptional activation; topoisomerase; top3b tdrd3 ... See more keywords
Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13792
Abstract: Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J and short-lived NZO/HILtJ mouse strains by profiling transcriptomes and epigenomes of immune… read more here.
Keywords: jun fos; transcriptional activation; activation jun; age ... See more keywords