Development of a Transcriptional Activator‐Like Effector Protein to Accurately Discriminate Single Nucleotide Difference
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200486
Abstract: Transcriptional activator‐like effector (TALE), a DNA‐binding protein, is widely used in genome editing. However, the recognition of the target sequence by the TALE is adversely affected by the number of mismatches. Therefore, the association constant… read more here.
Keywords: activator like; nucleotide difference; transcriptional activator; nucleotide ... See more keywords
TORC1 ensures membrane trafficking of Tat2 tryptophan permease via a novel transcriptional activator Vhr2 in budding yeast.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109542
Abstract: The target of rapamycin complex 1 (TORC1) protein kinase is activated by nutrients and controls nutrient uptake via the membrane trafficking of various nutrient permeases. However, its molecular mechanisms remain elusive. Cholesterol (ergosterol in yeast)… read more here.
Keywords: membrane trafficking; tryptophan permease; tat2; activator vhr2 ... See more keywords
Coexpression network analysis reveals an MYB transcriptional activator involved in capsaicinoid biosynthesis in hot peppers.
Sign Up to like & getrecommendations! Published in 2020 at "Horticulture research"
DOI: 10.1038/s41438-020-00381-2
Abstract: Plant biosynthesis involves numerous specialized metabolites with diverse chemical natures and biological activities. The biosynthesis of metabolites often exclusively occurs in response to tissue-specific combinatorial developmental cues that are controlled at the transcriptional level. Capsaicinoids… read more here.
Keywords: biosynthesis; capsaicinoid biosynthesis; coexpression network; transcriptional activator ... See more keywords
Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21194-3
Abstract: Tenomodulin (Tnmd) is a type II transmembrane glycoprotein predominantly expressed in tendons and ligaments. We found that scleraxis (Scx), a member of the Twist-family of basic helix-loop-helix transcription factors, is a transcriptional activator of Tnmd… read more here.
Keywords: tnmd; activator regulates; activator; tenomodulin ... See more keywords
Identification of a WRKY transcriptional activator from Camellia sinensis that regulates methylated EGCG biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "Horticulture Research"
DOI: 10.1093/hr/uhac024
Abstract: ABSTRACT Naturally occurring methylated catechins, especially methylated EGCG in tea leaves, are known to have many health benefits. Although the genes involved in methylated EGCG biosynthesis have been studied extensively, the transcription factors that control… read more here.
Keywords: cswrky57like; biosynthesis; methylated egcg; transcriptional activator ... See more keywords
Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.10.24.513549
Abstract: The GAL pathway of yeasts has long served as a model system for understanding of how regulatory mode of eukaryotic metabolic pathways evolves. While Gal4 mode has been well-characterized in Saccharomycetaceae clade, little is known… read more here.
Keywords: gal; recognition galactose; candida; transcriptional activator ... See more keywords
Control of solvent production by sigma‐54 factor and the transcriptional activator AdhR in Clostridium beijerinckii
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.13505
Abstract: Clostridia are obligate anaerobic bacteria that can produce solvents such as acetone, butanol and ethanol. Alcohol dehydrogenases (ADHs) play a key role in solvent production; however, their regulatory mechanisms remain largely unknown. In this study,… read more here.
Keywords: production; solvent production; beijerinckii; transcriptional activator ... See more keywords
Functional analysis of the transcriptional activator XlnR of Penicillium oxalicum.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied microbiology"
DOI: 10.1111/jam.15276
Abstract: AIMS The aim of this article is to study the functional features of Penicillium oxalicum transcriptional activator XlnR. METHODS AND RESULTS The yeast reporter system was used to identify transcriptional activation domain of XlnR in… read more here.
Keywords: xlnr; site; activator xlnr; transcriptional activator ... See more keywords
Targeting Transcriptional Co-Activator PGC-1a for the Treatment of Sickle Cell Disease
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-123959
Abstract: Sickle cell disease (SCD) is the most common inherited human hematologic disease, which causes hemolytic anemia, pain, disability, progressive multi-organ damage and early mortality. Clinical studies have shown that increased synthesis of fetal hemoglobin (HbF)… read more here.
Keywords: globin; activator pgc; disease; pgc ... See more keywords
Enhancing DNT Detection by a Bacterial Bioreporter: Directed Evolution of the Transcriptional Activator YhaJ
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.821835
Abstract: Detection of buried landmines is a dangerous and complicated task that consumes large financial resources and poses significant risks to the personnel involved. A potential alternative to conventional detection methodologies is the use of microbial… read more here.
Keywords: bioreporter directed; bioreporter; detection; directed evolution ... See more keywords