Acetylated Signal Transducer and Activator of Transcription 3 Functions as Molecular Adaptor Independent of Transcriptional Activity During Human Cardiogenesis
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2665
Abstract: Activation of signal transducer and activator of transcription 3 (STAT3) is imperative for mammalian development, specifically cardiogenesis. STAT3 phosphorylation and acetylation are key post‐translational modifications that regulate its transcriptional activity. Significance of such modifications during… read more here.
Keywords: transcription; molecular adaptor; activator; human cardiogenesis ... See more keywords
SUMOylation represses the transcriptional activity of the Unfolded Protein Response transducer ATF6.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.103
Abstract: The Unfolded Protein Response (UPR) is a cascade of intracellular stress signaling from the endoplasmic reticulum (ER) that protect the cells from the stress caused by accumulation of unfolded or misfolded proteins in the ER.… read more here.
Keywords: protein; sumoylation; atf6 protein; transcriptional activity ... See more keywords
Chronic low-dose pro-oxidant treatment stimulates transcriptional activity of telomeric retroelements and increases telomere length in Drosophila.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of insect physiology"
DOI: 10.1016/j.jinsphys.2017.11.002
Abstract: It has been proposed that oxidative stress, elicited by high levels of reactive oxygen species, accelerates telomere shortening by erosion of telomeric DNA repeats. While most eukaryotes counteract telomere shortening by telomerase-driven addition of these… read more here.
Keywords: telomeric retroelements; length; drosophila; telomere length ... See more keywords
SIRT1 is a transcriptional enhancer of the glucocorticoid receptor acting independently to its deacetylase activity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.012
Abstract: Glucocorticoids have strong effects on diverse human activities through the glucocorticoid receptor (GR). Sirtuin 1 (SIRT1) is a NAD+-dependent histone deacetylase and promotes longevity by influencing intermediary metabolism and other regulatory activities including mitochondrial function.… read more here.
Keywords: glucocorticoid receptor; transcriptional activity; transcriptional enhancer; deacetylase activity ... See more keywords
Sumoylation regulates the transcriptional activity of different human NFAT isoforms in neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.05.074
Abstract: In the nervous system, four calcium/calcineurin-regulated members of the nuclear factor of activated T-cells (NFAT) family of transcription factors, NFATc1-c4, are involved in many developmental and functional processes, such as corticogenesis, synaptogenesis, synaptic plasticity and… read more here.
Keywords: sumoylation; nfat isoforms; transcriptional activity; different human ... See more keywords
Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05891
Abstract: Transcription factor p53 regulates cellular responses to environmental perturbations via the transcriptional activation of downstream target genes. Inappropriate p53 activation can trigger abnormal cellular responses, therefore leading to acute or chronic tissue damage, human developmental… read more here.
Keywords: pq1; p53 transcriptional; transcriptional activity; p53 ... See more keywords
FERMT1 mediates epithelial–mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.339
Abstract: We previously demonstrated that fermitin family member 1 (FERMT1) was significantly overexpressed in colon cancer (CC) and associated with poor metastasis-free survival. This study aimed to investigate the precise role of FERMT1 in CC metastasis… read more here.
Keywords: catenin; colon; metastasis; transcriptional activity ... See more keywords
Recording transcriptional activity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Methods"
DOI: 10.1038/s41592-018-0242-5
Abstract: Acquisition of RNA into CRISPR arrays allows the recording of transcriptional dynamics in cells. read more here.
Keywords: transcriptional activity; recording transcriptional;
The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35243-4
Abstract: Active microbes likely have larger impact on gut health status compared to inactive or dormant microbes. We investigate the composition of active and total mucosal microbiota of treatment-naïve ulcerative colitis (UC) patients to determine the… read more here.
Keywords: transcriptional activity; colitis patients; ulcerative colitis; mucosal microbiota ... See more keywords
Interactions governing transcriptional activity of nuclear receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20220338
Abstract: The key players in transcriptional regulation are transcription factors (TFs), proteins that bind specific DNA sequences. Several mechanisms exist to turn TFs 'on' and 'off', including ligand binding which induces conformational changes within TFs, subsequently… read more here.
Keywords: nuclear receptors; transcriptional activity; governing transcriptional; activity ... See more keywords
Adeno associated virus serotype.
Sign Up to like & getrecommendations! Published in 2020 at "Human gene therapy"
DOI: 10.1089/hum.2019.274
Abstract: Adeno-associated viral vectors have been successfully used in laboratory and clinical settings for efficient gene delivery. In these vectors, 96% of the AAV genome is replaced with a gene cassette of interest, leaving only the… read more here.
Keywords: transgene expression; transcriptional activity; expression; serotype ... See more keywords