A Mechanochemical Model of Transcriptional Bursting.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.01.017
Abstract: Populations of genetically identical cells generally show a large variability in cell phenotypes, which is typically associated with the stochastic nature of gene expression processes. It is widely believed that a significant source of such… read more here.
Keywords: transcription; bursting; transcriptional bursting; model transcriptional ... See more keywords
BISC: accurate inference of transcriptional bursting kinetics from single-cell transcriptomic data
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac464
Abstract: Gene expression in mammalian cells is inherently stochastic and mRNAs are synthesized in discrete bursts. Single-cell transcriptomics provides an unprecedented opportunity to explore the transcriptome-wide kinetics of transcriptional bursting. However, current analysis methods provide limited… read more here.
Keywords: bursting; cell; bisc; cell transcriptomic ... See more keywords
Inferring transcriptional bursting kinetics from single-cell snapshot data using a generalized telegraph model
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.221057
Abstract: Motivation Gene expression has inherent stochasticity resulting from transcription’s burst manners. Single-cell snapshot data can be exploited to rigorously infer transcriptional burst kinetics, using mathematical models as blueprints. The classical telegraph model (CTM) has been… read more here.
Keywords: bursting; cell snapshot; transcriptional bursting; burst ... See more keywords
A transcriptional cycling model recapitulates chromatin-dependent features of noisy inducible transcription
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1101/2022.05.03.490387
Abstract: Activation of gene expression in response to environmental cues results in substantial phenotypic heterogeneity between cells that can impact a wide range of outcomes including differentiation, viral activation, and drug resistance. An important source of… read more here.
Keywords: transcription; expression; transcriptional bursting; model ... See more keywords
3 ′-5 ′ crosstalk contributes to transcriptional bursting
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DOI: 10.1186/s13059-020-02227-5
Abstract: Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in… read more here.
Keywords: bursting; crosstalk contributes; transcriptional bursting; contributes transcriptional ... See more keywords
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008772
Abstract: Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic and allele-biased expression observed… read more here.
Keywords: monoallelic expression; transcriptional bursting; transcriptional bursts; expression ... See more keywords
Transcriptional bursting in Drosophila development: Stochastic dynamics of eve stripe 2 expression
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176228
Abstract: Anterior-posterior (AP) body segmentation of the fruit fly (Drosophila) is first seen in the 7-stripe spatial expression patterns of the pair-rule genes, which regulate downstream genes determining specific segment identities. Regulation of pair-rule expression has… read more here.
Keywords: drosophila; eve stripe; transcription; time ... See more keywords