Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1008772
Abstract: Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic and allele-biased expression observed… read more here.
Keywords: monoallelic expression; transcriptional bursting; transcriptional bursts; expression ... See more keywords
Transcriptional bursts and heterogeneity among cardiomyocytes in hypertrophic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.987889
Abstract: Transcriptional bursting is a common expression mode for most genes where independent transcription of alleles leads to different ratios of allelic mRNA from cell to cell. Here we investigated burst-like transcription and its consequences in… read more here.
Keywords: hypertrophic cardiomyopathy; bursts heterogeneity; burst like; hcm patients ... See more keywords