A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex
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DOI: 10.1038/s41467-021-27533-9
Abstract: The molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not fully understood. Here, we report that Brazilian green propolis reduces fasting blood glucose levels in obese mice by disrupting the formation of CREB/CRTC2… read more here.
Keywords: metabolic syndrome; obese mice; creb crtc2; transcriptional complex ... See more keywords
Aurintricarboxylic acid is a canonical disruptor of the TAZ-TEAD transcriptional complex
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DOI: 10.1371/journal.pone.0266143
Abstract: Disrupting the formation of the oncogenic YAP/TAZ-TEAD transcriptional complex holds substantial therapeutic potential. However, the three protein interaction interfaces of this complex cannot be easily disrupted using small molecules. Here, we report that the pharmacologically… read more here.
Keywords: taz; aurintricarboxylic acid; taz tead; transcriptional complex ... See more keywords