Transcriptional condensates and phase separation: condensing information across scales and mechanisms
Sign Up to like & getrecommendations! Published in 2023 at "Nucleus"
DOI: 10.1080/19491034.2023.2213551
Abstract: ABSTRACT Transcription is the fundamental process of gene expression, which in eukaryotes occurs within the complex physicochemical environment of the nucleus. Decades of research have provided extreme detail in the molecular and functional mechanisms of… read more here.
Keywords: phase separation; transcription; separation condensing; transcriptional condensates ... See more keywords
SEGCOND predicts putative transcriptional condensate-associated genomic regions by integrating multi-omics data
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DOI: 10.1093/bioinformatics/btac742
Abstract: Abstract Motivation The compartmentalization of biochemical reactions, involved in the activation of gene expression in the eukaryotic nucleus, leads to the formation of membraneless bodies through liquid–liquid phase separation. These formations, called transcriptional condensates, appear… read more here.
Keywords: predicts putative; segcond predicts; transcriptional condensates; genomic regions ... See more keywords
Heterotypic transcriptional condensates formed by prion-like paralogous proteins canalize flowering transition in tomato
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DOI: 10.1186/s13059-022-02646-6
Abstract: Background Paralogs that arise from gene duplications during genome evolution enable genetic redundancy and phenotypic robustness. Variation in the coding or regulatory sequence of paralogous transcriptional regulators diversifies their functions and relationships, which provides developmental… read more here.
Keywords: condensates formed; flowering transition; prion like; heterotypic transcriptional ... See more keywords