Transcriptional control of macrophage polarisation in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-019-00748-1
Abstract: Type-2 diabetes (T2D) is considered today as an inflammatory disease. Inflammatory processes in T2D are orchestrated by macrophage activation in different organs. Macrophages undergo classical M1 pro-inflammatory or alternative M2 anti-inflammatory activation in response to… read more here.
Keywords: transcriptional control; macrophage polarisation; type diabetes; macrophage ... See more keywords
Post-transcriptional control of gene expression following stress: the role of RNA-binding proteins
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society Transactions"
DOI: 10.1042/bst20160364
Abstract: The ability of mammalian cells to modulate global protein synthesis in response to cellular stress is essential for cell survival. While control of protein synthesis is mediated by the regulation of eukaryotic initiation and elongation… read more here.
Keywords: transcriptional control; binding proteins; post transcriptional; rna ... See more keywords
Small-molecule inducible transcriptional control in mammalian cells
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2020.1808583
Abstract: Abstract Tools for tuning transcription in mammalian cells have broad applications, from basic biological discovery to human gene therapy. While precise control over target gene transcription via dosing with small molecules (drugs) is highly sought,… read more here.
Keywords: transcriptional control; control; small molecule; biology ... See more keywords
Post-transcriptional control of hemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad046
Abstract: The hemostatic system is pivotal to maintaining vascular integrity. Multiple components involved in blood coagulation have central functions in inflammation and immunity. A derailed hemostasis is common in prevalent pathologies such as sepsis, cardiovascular disorders… read more here.
Keywords: system; transcriptional control; therapeutic concepts; hemostatic system ... See more keywords
Transcriptional control of proteostasis
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.371.6524.39-n
Abstract: Stress Responses Tissue homeostasis requires the coordinated activity of multiple cell types to initiate and then resolve inflammation. Intrinsic cellular stress-response pathways facilitate adaptation to stress and tissue restitution. Among these stress pathways, the unfolded… read more here.
Keywords: transcriptional control; science; stress; control proteostasis ... See more keywords
Transcriptional control of kidney cancer
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.aau4385
Abstract: Stabilization of the transcription factor ZHX2 promotes kidney tumor growth Clear cell renal cell carcinoma (ccRCC) is a subtype of kidney cancer characterized by inactivation of the von Hippel-Lindau (VHL) gene in ∼90% of patients.… read more here.
Keywords: transcriptional control; transcription; kidney cancer; control kidney ... See more keywords
Post-transcriptional control of miRNA biogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "RNA"
DOI: 10.1261/rna.068692.118
Abstract: MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear and cytoplasmic processing events, carried out by the endoribonucleases DROSHA and DICER, respectively,… read more here.
Keywords: transcriptional control; control; post transcriptional; control mirna ... See more keywords
Transcriptional Control of Metastasis by Integrated Stress Response Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.770843
Abstract: As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation… read more here.
Keywords: transcriptional control; integrated stress; metastasis; stress response ... See more keywords
A Novel Role of PM Extracts on the Post-Transcriptional Control of Pro-Inflammatory Mediators, IL-6 and CXCL8
Sign Up to like & getrecommendations! Published in 2019 at "Atmosphere"
DOI: 10.3390/atmos10050270
Abstract: Exposure to airborne particulate matter (PM) has been associated with the transcriptional up-regulation of pro-inflammatory mediators. However, the effect of PM on post-transcriptional regulation of pro-inflammatory mediators has not been fully explored. In this study,… read more here.
Keywords: pro inflammatory; dep extracts; transcriptional control; post transcriptional ... See more keywords
Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12041034
Abstract: Clinical results with oncolytic adenoviruses (OAds) used as antitumor monotherapies show limited efficacy. To increase OAd potency, transgenes have been inserted into their genome, a strategy known as “arming OAds”. Here, we review different parameters… read more here.
Keywords: transcriptional control; control elements; oncolytic adenoviruses; transgene location ... See more keywords