A PML/RARĪ± direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.
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DOI: 10.1182/blood.2020005698
Abstract: Transcriptional deregulation initiated by oncogenic fusion proteins plays a vital role in leukemia. The prevailing view is that the oncogenic fusion protein PML/RARĪ±, generated by the chromosome translocation t(15;17), functions as a transcriptional repressor in… read more here.
Keywords: rar; transcriptional deregulation; leukemia; pml rar ... See more keywords