Developmental Transcriptional Enhancers: A Subtle Interplay between Accessibility and Activity
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DOI: 10.1002/bies.201900188
Abstract: Measurements of open chromatin in specific cell types are widely used to infer the spatiotemporal activity of transcriptional enhancers. How reliable are these predictions? In this review, it is argued that the relationship between the… read more here.
Keywords: transcriptional enhancers; developmental transcriptional; accessibility; enhancers subtle ... See more keywords
Pancreatic Islet Transcriptional Enhancers and Diabetes
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DOI: 10.1007/s11892-019-1230-6
Abstract: Common genetic variants that associate with type 2 diabetes risk are markedly enriched in pancreatic islet transcriptional enhancers. This review discusses current advances in the annotation of islet enhancer variants and their target genes. Recent… read more here.
Keywords: pancreatic islet; enhancers diabetes; transcriptional enhancers; islet ... See more keywords
Identification of new Anopheles gambiae transcriptional enhancers using a cross‐species prediction approach
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DOI: 10.1111/imb.12705
Abstract: The success of transgenic mosquito vector control approaches relies on well‐targeted gene expression, requiring the identification and characterization of a diverse set of mosquito promoters and transcriptional enhancers. However, few enhancers have been characterized in… read more here.
Keywords: identification new; transcriptional enhancers; biology; anopheles gambiae ... See more keywords
Transcriptional enhancers: from prediction to functional assessment on a genome-wide scale.
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DOI: 10.1139/gen-2020-0104
Abstract: Enhancers are cis-regulatory sequences located distally to target genes. These sequences consolidate developmental and environmental cues to coordinate gene expression in a tissue-specific manner. Enhancer function and tissue specificity depend on the expressed set of… read more here.
Keywords: prediction functional; genome wide; functional assessment; transcriptional enhancers ... See more keywords
Transcriptional Enhancers in Drosophila.
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DOI: 10.1534/genetics.120.301370
Abstract: Key discoveries in Drosophila have shaped our understanding of cellular "enhancers." With a special focus on the fly, this chapter surveys properties of these adaptable cis-regulatory elements, whose actions are critical for the complex spatial/temporal… read more here.
Keywords: transcriptional enhancers; genetics; biology; enhancers drosophila ... See more keywords