Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers
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DOI: 10.1371/journal.pgen.1010235
Abstract: The transcription factor NF-κB, which plays an important role in cell fate determination, is involved in the activation of super-enhancers (SEs). However, the biological functions of the NF-κB SEs in gene control are not fully… read more here.
Keywords: cell; mediated super; heterogeneity mediated; transcriptional heterogeneity ... See more keywords
Transcriptional Heterogeneity of Cellular Senescence in Cancer
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DOI: 10.14348/molcells.2022.0036
Abstract: Cellular senescence plays a paradoxical role in tumorigenesis through the expression of diverse senescence-associated (SA) secretory phenotypes (SASPs). The heterogeneity of SA gene expression in cancer cells not only promotes cancer stemness but also protects… read more here.
Keywords: scrna seq; transcriptional heterogeneity; senescence; cellular senescence ... See more keywords
Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain
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DOI: 10.7554/elife.71864
Abstract: The ventricular zone (VZ) of the nervous system contains radial glia cells that were originally considered relatively homogenous in their gene expression, but a detailed characterization of transcriptional diversity in these VZ cells has not… read more here.
Keywords: transcriptional heterogeneity; zone; heterogeneity ventricular; ventricular zone ... See more keywords