Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01141
Abstract: MicroRNAs (miRNAs) are noncoding RNA molecules of 22-24 nucleotides that are estimated to regulate thousands of genes in humans, and their dysregulation has been implicated in many diseases. MicroRNA-122 (miR-122) is the most abundant miRNA… read more here.
Keywords: liver; mir 122; liver cells; hepatitis virus ... See more keywords
Nuclear speckle fusion via long-range directional motion regulates speckle morphology after transcriptional inhibition
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.226563
Abstract: ABSTRACT Although the formation of RNA-protein bodies has been studied intensively, their mobility and how their number and size are regulated are still poorly understood. Here, we show significantly increased mobility of nuclear speckles after… read more here.
Keywords: nuclear speckle; speckle; long range; transcriptional inhibition ... See more keywords