A human somatic cell culture system for modelling gene silencing by transcriptional interference
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03261
Abstract: Transcriptional interference and transcription through regulatory elements (transcriptional read-through) are implicated in gene silencing and the establishment of DNA methylation. Transcriptional read-through is needed to seed DNA methylation at imprinted genes in the germ line… read more here.
Keywords: transcriptional read; dna; transcriptional interference; gene ... See more keywords
Engineering Transcriptional Interference through RNA Polymerase Processivity Control.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.0c00534
Abstract: Antisense transcription is widespread in all kingdoms of life and has been shown to influence gene expression through transcriptional interference (TI), a phenomenon in which one transcriptional process negatively influences another in cis. The processivity,… read more here.
Keywords: transcriptional interference; biology; processivity; processivity control ... See more keywords
Transcriptional Interference in Toehold Switch-Based RNA Circuits.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00486
Abstract: Gene regulation based on regulatory RNA is an important mechanism in cells and is increasingly used for regulatory circuits in synthetic biology. Toehold switches are rationally designed post-transcriptional riboregulators placed in the 5' untranslated region… read more here.
Keywords: promoter; rna; toehold switch; transcriptional interference ... See more keywords
Characterizing Transcriptional Interference between Converging Genes in Bacteria.
Sign Up to like & getrecommendations! Published in 2019 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00477
Abstract: Antisense transcription is common in naturally occurring genomes and is increasingly being used in synthetic genetic circuitry as a tool for gene expression control. Mutual influence on the expression of convergent genes can be mediated… read more here.
Keywords: characterizing transcriptional; interference; rna polymerase; interference converging ... See more keywords