Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19
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DOI: 10.1016/j.isci.2021.103325
Abstract: In parasite and viral infections, aberrant B cell responses can suppress germinal center reactions thereby blunting long-lived memory and may provoke immunopathology including autoimmunity. Using COVID-19 as model, we set out to identify serological, cellular… read more here.
Keywords: transcriptional landscape; plasmablasts autoreactive; autoreactive cells; landscape plasmablasts ... See more keywords
Transcriptional landscape of human endogenous retroviruses (HERVs) and other repetitive elements in psoriatic skin
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22734-7
Abstract: Human endogenous retrovirus (HERV) sequences make up at least 8% of the human genome. Transcripts originating from these loci as well as proteins encoded by them have been detected in various tissues. HERVs are believed… read more here.
Keywords: psoriatic skin; hervs repetitive; transcriptional landscape; repetitive elements ... See more keywords
Dynamics of the transcriptional landscape during human fetal testis and ovary development.
Sign Up to like & getrecommendations! Published in 2020 at "Human reproduction"
DOI: 10.1093/humrep/deaa041
Abstract: STUDY QUESTION Which transcriptional program triggers sex differentiation in bipotential gonads and downstream cellular events governing fetal testis and ovary development in humans? SUMMARY ANSWER The characterization of a dynamically regulated protein-coding and non-coding transcriptional… read more here.
Keywords: human fetal; transcriptional landscape; non coding; expression ... See more keywords
611 RNA-sequencing reveals a unique immune transcriptional landscape in the vaccine sites of patients with circulating T-cell responses to cancer immunization
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0611
Abstract: Background Vaccines are a promising therapeutic for patients with advanced cancer, but achieving robust T-cell responses remains a challenge. Melanoma-associated antigen-A3 (MAGE-A3) in combination with adjuvant AS15 (a formulation of Toll-Like-Receptor (TLR)-4 and 9 agonists… read more here.
Keywords: cell responses; figure; transcriptional landscape; cancer ... See more keywords
The transcriptional landscape of basidiosporogenesis in mature Pisolithus microcarpus basidiocarp
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DOI: 10.1186/s12864-017-3545-5
Abstract: BackgroundPisolithus microcarpus (Cooke & Massee) G. Cunn is a gasteromycete that produces closed basidiocarps in symbiosis with eucalypts and acacias. The fungus produces a complex basidiocarp composed of peridioles at different developmental stages and an… read more here.
Keywords: basidiosporogenesis; developmental stages; transcriptional landscape; expression ... See more keywords
Making the clock tick: the transcriptional landscape of the plant circadian clock
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DOI: 10.12688/f1000research.11319.1
Abstract: Circadian clocks are molecular timekeepers that synchronise internal physiological processes with the external environment by integrating light and temperature stimuli. As in other eukaryotic organisms, circadian rhythms in plants are largely generated by an array… read more here.
Keywords: making clock; circadian clock; transcriptional landscape; clock tick ... See more keywords
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence
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DOI: 10.1371/journal.ppat.1007461
Abstract: Efficient and highly organized regulation of transcription is fundamental to an organism’s ability to survive, proliferate, and quickly respond to its environment. Therefore, precise mapping of transcriptional units and understanding their regulation is crucial to… read more here.
Keywords: reveals complex; virulence; transcriptional landscape; streptococcus pneumoniae ... See more keywords
Transcriptional landscape of human cancers
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DOI: 10.18632/oncotarget.15837
Abstract: The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively explored. However, the related exploration based on transcriptome data is lacking. In this study we explored… read more here.
Keywords: cancer types; human cancers; transcriptional landscape; cancer ... See more keywords
The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets
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DOI: 10.26508/lsa.202000651
Abstract: Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several… read more here.
Keywords: basal cell; cell; bcc; transcriptional landscape ... See more keywords
Transcriptional Landscape of Cotton Fiber Development and Its Alliance With Fiber-Associated Traits
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.811655
Abstract: Cotton fiber development is still an intriguing question to understand fiber commitment and development. At different fiber developmental stages, many genes change their expression pattern and have a pivotal role in fiber quality and yield.… read more here.
Keywords: cotton; fiber; cotton fiber; fiber development ... See more keywords
Transcriptional Landscape of PARs in Epithelial Malignancies
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19113451
Abstract: G protein-coupled receptors (GPCRs), the largest family of cell receptors, act as important regulators of diverse signaling pathways. Our understanding of the impact of GPCRs in tumors is emerging, yet there is no therapeutic platform… read more here.
Keywords: pars epithelial; transcriptional landscape; promoter; landscape pars ... See more keywords