Targeting transcriptional machinery to inhibit enhancer-driven gene expression in heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Heart Failure Reviews"
DOI: 10.1007/s10741-019-09792-3
Abstract: Pathological cardiac remodeling is induced through multiple mechanisms that include neurohumoral and biomechanical stress resulting in transcriptional alterations that ultimately become maladaptive and lead to the development of heart failure (HF). Although cardiac transcriptional remodeling… read more here.
Keywords: transcriptional machinery; pro hypertrophic; heart failure;
The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001548
Abstract: Commitment to cell division at the end of G1 phase, termed Start in the budding yeast Saccharomyces cerevisiae, is strongly influenced by nutrient availability. To identify new dominant activators of Start that might operate under… read more here.
Keywords: start; rewires transcriptional; transcriptional machinery; budding yeast ... See more keywords
Targeting the Heterogeneous Genomic Landscape in Triple-Negative Breast Cancer through Inhibitors of the Transcriptional Machinery
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DOI: 10.3390/cancers14184353
Abstract: Simple Summary Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with limited options for therapy. Cancer development and maintenance is dependent on the production of oncogenic proteins. In TNBC, the production… read more here.
Keywords: production; breast cancer; cancer; transcriptional machinery ... See more keywords
A Review of the Multipronged Attack of Herpes Simplex Virus 1 on the Host Transcriptional Machinery
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DOI: 10.3390/v13091836
Abstract: During lytic infection, herpes simplex virus (HSV) 1 induces a rapid shutoff of host RNA synthesis while redirecting transcriptional machinery to viral genes. In addition to being a major human pathogen, there is burgeoning clinical… read more here.
Keywords: simplex virus; transcriptional machinery; review multipronged; herpes simplex ... See more keywords