Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.03.011
Abstract: ABSTRACT Diabetic peripheral neuropathy is the most common complication of diabetes and a source of considerable morbidity. Numerous molecular pathways are linked to neuropathic progression, but it is unclear whether these pathways are altered throughout… read more here.
Keywords: analysis; peripheral neuropathy; scn drg; transcriptional networks ... See more keywords
Immune Responses - Transcriptional and Post-Transcriptional Networks Pass the Baton.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2017.11.003
Abstract: Diverse gene regulatory mechanisms impact on immune homeostasis, and a new model now emerges as fundamental in light of recent genome-wide studies. In this picture, transcriptional networks drive functional changes during immune activation, whereas autoregulatory… read more here.
Keywords: post transcriptional; immune responses; transcriptional post; transcriptional networks ... See more keywords
Experimental noise cutoff boosts inferability of transcriptional networks in large-scale gene-deletion studies
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02489-x
Abstract: Generating a comprehensive map of molecular interactions in living cells is difficult and great efforts are undertaken to infer molecular interactions from large-scale perturbation experiments. Here, we develop the analytical and numerical tools to quantify… read more here.
Keywords: large scale; network; transcriptional networks; network inference ... See more keywords
14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy051
Abstract: In humans, fetal erythropoiesis takes place in the liver whereas adult erythropoiesis occurs in the bone marrow. Fetal and adult erythroid cells are not only produced at different sites, but are also distinguished by their… read more here.
Keywords: adult; hemoglobin; adult human; fetal adult ... See more keywords
HMGA1 Chromatin Regulators Induce Transcriptional Networks Involved in GATA2 and Proliferation During MPN Progression.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021013925
Abstract: Myeloproliferative neoplasms (MPN) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although actionable mechanisms driving progression remain elusive. Here, we elucidate the role of the High Mobility Group A1 (HMGA1) chromatin regulator… read more here.
Keywords: hmga1; proliferation; hmga1 chromatin; mpn ... See more keywords