Divergent transcriptional profiles in pediatric asthma patients of low and high socioeconomic status
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Pulmonology"
DOI: 10.1002/ppul.23983
Abstract: There are marked socioeconomic disparities in pediatric asthma control, but the molecular origins of these disparities are not well understood. To fill this gap, we performed genome‐wide expression profiling of monocytes and T‐helper cells from… read more here.
Keywords: transcriptional profiles; asthma patients; pediatric asthma; socioeconomic status ... See more keywords
Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.05.021
Abstract: Activation and recruitment of thermogenic cells in human white adipose tissues ("browning") can counteract obesity and associated metabolic disorders. However, quantifying the effects of therapeutic interventions on browning remains enigmatic. Here, we devise a computational… read more here.
Keywords: adipose browning; prediction adipose; transcriptional profiles; browning capacity ... See more keywords
Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11948-6
Abstract: The Mycobacterium tuberculosis complex (MTBC) members display different host-specificities and virulence phenotypes. Here, we have performed a comprehensive RNAseq and methylome analysis of the main clades of the MTBC and discovered unique transcriptional profiles. The… read more here.
Keywords: genome wide; transcriptional profiles; tuberculosis complex; mycobacterium tuberculosis ... See more keywords
Transcriptional profiles of genes related to mitochondrial aging in placental pathologies.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular human reproduction"
DOI: 10.1093/molehr/gaac026
Abstract: As the placenta develops across gestation, the mitochondria and other organelles like the endoplasmic reticulum (ER) must continue to adapt to stressors such as oxidative stress. As pregnancy approaches term, these stressors may contribute to… read more here.
Keywords: genes related; profiles genes; related mitochondrial; mitochondrial aging ... See more keywords
Cell composition inference and identification of layer-specific spatial transcriptional profiles with POLARIS
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add9818
Abstract: Spatial transcriptomics (ST) technology, providing spatially resolved transcriptional profiles, facilitates advanced understanding of key biological processes related to health and disease. Sequencing-based ST technologies provide whole-transcriptome profiles but are limited by the non–single cell–level resolution.… read more here.
Keywords: cell; composition inference; composition; layer ... See more keywords
Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3464
Abstract: Missense mutations in the DNA binding domain of p53 are characterized as structural or contact mutations based on their effect on the conformation of the protein. These mutations show gain-of-function activities, such as promoting increased… read more here.
Keywords: profiles underlie; p53 mutants; underlie osteosarcomagenesis; transcriptional profiles ... See more keywords
Single Cell RNASeq Demonstrates That Mouse Erythroid Cells Are the Last Lineage to Emerge
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110318
Abstract: The hierarchical model of hematopoiesis posits that hematopoietic stem cells (HSC) give rise to myeloid progenitors (CMP), that can become further restricted to bipotential granulocyte/monocyte progenitors (GMP) or megakaryocyte/erythroid progenitors (MEP). We and others have… read more here.
Keywords: ery; transcriptional profiles; lineage; cmp ... See more keywords
Skin transcriptional profiles in Oophaga poison frogs
Sign Up to like & getrecommendations! Published in 2020 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2019-0401
Abstract: Abstract Aposematic organisms advertise their defensive toxins to predators using a variety of warning signals, including bright coloration. While most Neotropical poison frogs (Dendrobatidae) rely on crypsis to avoid predators, Oophaga poison frogs from South… read more here.
Keywords: transcriptional profiles; oophaga poison; skin transcriptional; poison frogs ... See more keywords
Medullary Thyroid Carcinoma Mutational Spectrum Update and Signaling-Type Inference by Transcriptional Profiles: Literature Meta-Analysis and Study of Tumor Samples
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14081951
Abstract: Simple Summary Medullary thyroid carcinoma (MTC) is a rare but clinically relevant tumor based on its aggressiveness and the limited therapeutic opportunities currently available for advanced cases. A better understanding of the mechanisms of MTC… read more here.
Keywords: thyroid carcinoma; mtc; transcriptional profiles; medullary thyroid ... See more keywords
Differences in Whole-Blood Transcriptional Profiles in Inflammatory Bowel Disease Patients Responding to Vedolizumab Compared with Non-Responders
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065820
Abstract: Vedolizumab is efficacious in the treatment of Crohn’s disease (CD) and ulcerative colitis (UC). However, a significant proportion of patients present with a non-response. To investigate whether differences in the clinical response to vedolizumab is… read more here.
Keywords: non responders; patients responding; transcriptional profiles; whole blood ... See more keywords