Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12923
Abstract: The epigenomic regulation of transcriptional programs in metastatic prostate cancer is poorly understood. We studied the epigenomic landscape of prostate cancer drivers using transcriptional profiling and ChIP‐seq in four clonal metastatic tumors derived from a… read more here.
Keywords: prostate; core transcriptional; prostate cancer; transcriptional program ... See more keywords
Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivo
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23671
Abstract: α‐Synucleinopathies are neurodegenerative diseases that are characterized pathologically by α‐synuclein inclusions in neurons and glia. The pathologic contribution of glial α‐synuclein in these diseases is not well understood. Glial α‐synuclein may be of particular importance… read more here.
Keywords: synuclein; vivo; expression synuclein; glial synuclein ... See more keywords
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2020.12.025
Abstract: The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape and transcriptional… read more here.
Keywords: p53 central; neurodegeneration; c9orf72; p53 ... See more keywords
Rbf Activates the Myogenic Transcriptional Program to Promote Skeletal Muscle Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.080
Abstract: SUMMARY The importance of the retinoblastoma tumor suppressor protein pRB in cell cycle control is well established. However, less is known about its role in differentiation during animal development. Here, we investigated the role of… read more here.
Keywords: myogenic transcriptional; muscle; rbf; differentiation ... See more keywords
The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3667
Abstract: Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell… read more here.
Keywords: th2 transcriptional; treg cells; transcription; development ... See more keywords
OBF1 and Oct factors control the germinal center transcriptional program.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020010175
Abstract: OBF1 is a specific coactivator of the POU family transcription factors OCT1 and OCT2. OBF1 and OCT2 are B cell-specific and indispensable for germinal center (GC) formation, but their mechanism of action is unclear. Here,… read more here.
Keywords: germinal center; oct1 oct2; program; obf1 ... See more keywords
Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1007353
Abstract: Environmental or genetic perturbations lead to gene expression changes. While most analyses of these changes emphasize the presence of qualitative differences on just a few genes, we now know that changes are widespread. This large-scale… read more here.
Keywords: global transcriptional; gene expression; expression; regulation ... See more keywords
Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282418
Abstract: Clinical trials have shown that lentiviral-mediated gene therapy can ameliorate bone marrow failure (BMF) in non-conditioned Fanconi anemia (FA) patients resulting from the proliferative advantage of corrected FA HSPCs, however it is yet unknown if… read more here.
Keywords: hspcs; transcriptional program; gene; gene therapy ... See more keywords