Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
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DOI: 10.1016/j.celrep.2019.12.062
Abstract: SUMMARY Efficient and homogeneous in vitro generation of peripheral sensory neurons may provide a framework for novel drug screening platforms and disease models of touch and pain. We discover that, by ovesssrexpressing NGN2 and BRN3A,… read more here.
Keywords: neuron subtypes; neuron; pluripotent stem; stem ... See more keywords
Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma
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DOI: 10.1016/j.celrep.2021.108870
Abstract: SUMMARY Ibrutinib, a bruton’s tyrosine kinase (BTK) inhibitor, provokes robust clinical responses in aggressive mantle cell lymphoma (MCL), yet many patients relapse with lethal Ibrutinib-resistant (IR) disease. Here, using genomic, chemical proteomic, and drug screen… read more here.
Keywords: evolution; mantle cell; cell; transcriptional programming ... See more keywords
Corrigendum: Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18
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DOI: 10.3389/fimmu.2020.01367
Abstract: [This corrects the article DOI: 10.3389/fimmu.2019.02206.]. read more here.
Keywords: defective transcriptional; cd8 cells; effector cd8; programming effector ... See more keywords
Transcriptional programming of immunoregulatory responses in human Langerhans cells
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DOI: 10.3389/fimmu.2022.892254
Abstract: Human epidermal Langerhans cells (LCs) maintain immune homeostasis in the skin. To examine transcriptional programming of human primary LCs during homeostasis, we performed scRNA-seq analysis of LCs before and after migration from the epidermis, coupled… read more here.
Keywords: programming immunoregulatory; langerhans cells; responses human; migration ... See more keywords