Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24016
Abstract: Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensively investigated so… read more here.
Keywords: transcriptional programs; region specific; epigenetic control; cortical astrocytes ... See more keywords
Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.07.002
Abstract: Understanding the basis of cellular differentiation is a fundamental issue in developmental biology but also for the comprehension of pathological processes. In fact, the palette of developmental decisions for naive CD4 T cells is a… read more here.
Keywords: cd4 cells; transcriptional programs; biology; differentiation ... See more keywords
Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115716
Abstract: Osteosarcoma is an aggressive tumor of the bone that primarily affects young adults and adolescents. Osteosarcoma is characterized by genomic chaos and heterogeneity. While inactivation of tumor protein p53 (TP53) is nearly universal other high… read more here.
Keywords: methylation; transcriptional programs; human canine; conserved transcriptional ... See more keywords
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.049
Abstract: EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs.… read more here.
Keywords: ewsr1 fli1; transcriptional programs; heterogeneity; ewing sarcoma ... See more keywords
Isotype-specific plasma cells express divergent transcriptional programs
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121260119
Abstract: Significance During infection, antibodies are produced to target the rapid clearance of initial pathogen with high-affinity variants used long term to protect against reinfection. Under the guidance of CD4 T cell regulation, different subtypes of… read more here.
Keywords: divergent transcriptional; plasma cells; transcriptional programs; specific plasma ... See more keywords
DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky953
Abstract: Abstract Cortical development is controlled by transcriptional programs, which are orchestrated by transcription factors. Yet, stable inheritance of spatio-temporal activity of factors influencing cell fate and localization in different layers is only partly understood. Here… read more here.
Keywords: transcriptional programs; layer; layer identity; upper layer ... See more keywords
Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125202
Abstract: c-Myc plays a pivotal role in multiple myeloma (MM) pathogenesis; and the BET protein BRD4 is a key regulator of c-Myc transcription. Recently, a pathophysiologic role in MM has also been attributed to the AP-1… read more here.
Keywords: transcriptional programs; protein levels; myc junb; junb ... See more keywords
Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0404-17.2017
Abstract: Abstract Vital motor functions, such as respiration and locomotion, rely on the ability of spinal motor neurons (MNs) to acquire stereotypical positions in the ventral spinal cord and to project with high precision to their… read more here.
Keywords: transcriptional programs; connectivity; hox pbx; motor ... See more keywords
Robust Acquisition of Spatial Transcriptional Programs in Tissues With Immunofluorescence-Guided Laser Capture Microdissection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.853188
Abstract: The functioning of tissues is fundamentally dependent upon not only the phenotypes of the constituent cells but also their spatial organization in the tissue, as local interactions precipitate intra-cellular events that often lead to changes… read more here.
Keywords: capture microdissection; laser capture; transcriptional programs; immunofluorescence guided ... See more keywords
Rehabilitative Impact of Exercise Training on Human Skeletal Muscle Transcriptional Programs in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00653
Abstract: Parkinson’s disease (PD) is the most common motor neurodegenerative disease, and neuromuscular function deficits associated with PD contribute to disability. Targeting these symptoms, our laboratory has previously evaluated 16-week high-intensity resistance exercise as rehabilitative training… read more here.
Keywords: skeletal muscle; transcriptional programs; muscle; muscle transcriptional ... See more keywords
Modular transcriptional programs separately define axon and dendrite connectivity
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.50822
Abstract: Patterns of synaptic connectivity are remarkably precise and complex. Single-cell RNA sequencing has revealed a vast transcriptional diversity of neurons. Nevertheless, a clear logic underlying the transcriptional control of neuronal connectivity has yet to emerge.… read more here.
Keywords: modular transcriptional; define axon; transcriptional programs; programs separately ... See more keywords