Epigenetic control of region‐specific transcriptional programs in mouse cerebellar and cortical astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24016
Abstract: Astrocytes from the cerebral cortex (CTX) and cerebellum (CB) share basic molecular programs, but also form distinct spatial and functional subtypes. The regulatory epigenetic layers controlling such regional diversity have not been comprehensively investigated so… read more here.
Keywords: transcriptional programs; region specific; epigenetic control; cortical astrocytes ... See more keywords
Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.07.002
Abstract: Understanding the basis of cellular differentiation is a fundamental issue in developmental biology but also for the comprehension of pathological processes. In fact, the palette of developmental decisions for naive CD4 T cells is a… read more here.
Keywords: cd4 cells; transcriptional programs; biology; differentiation ... See more keywords
Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115716
Abstract: Osteosarcoma is an aggressive tumor of the bone that primarily affects young adults and adolescents. Osteosarcoma is characterized by genomic chaos and heterogeneity. While inactivation of tumor protein p53 (TP53) is nearly universal other high… read more here.
Keywords: methylation; transcriptional programs; human canine; conserved transcriptional ... See more keywords
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.049
Abstract: EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs.… read more here.
Keywords: ewsr1 fli1; transcriptional programs; heterogeneity; ewing sarcoma ... See more keywords
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06723-3
Abstract: Stroke causes death of brain tissue leading to long-term deficits. Behavioral evidence from neurorehabilitative therapies suggest learning-induced neuroplasticity can lead to beneficial outcomes. However, molecular and cellular mechanisms that link learning and stroke recovery are… read more here.
Keywords: activity dependent; dependent transcriptional; activity; transcriptional programs ... See more keywords
Isotype-specific plasma cells express divergent transcriptional programs
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121260119
Abstract: Significance During infection, antibodies are produced to target the rapid clearance of initial pathogen with high-affinity variants used long term to protect against reinfection. Under the guidance of CD4 T cell regulation, different subtypes of… read more here.
Keywords: divergent transcriptional; plasma cells; transcriptional programs; specific plasma ... See more keywords
Transcriptional programs of cell identity and p53-induced stress responses are associated with distinctive features of spatial genome organization
Sign Up to like & getrecommendations! Published in 2025 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaf607
Abstract: Abstract To date, most studies explored changes in 3D-genome organization between different tissues or during differentiation, which involve massive reprogramming of transcriptional programs. Much fewer studies examined alterations in genome organization in response to cellular… read more here.
Keywords: genome organization; p53; cell identity; transcriptional programs ... See more keywords
DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky953
Abstract: Abstract Cortical development is controlled by transcriptional programs, which are orchestrated by transcription factors. Yet, stable inheritance of spatio-temporal activity of factors influencing cell fate and localization in different layers is only partly understood. Here… read more here.
Keywords: transcriptional programs; layer; layer identity; upper layer ... See more keywords
ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs.
Sign Up to like & getrecommendations! Published in 2024 at "Cancer research"
DOI: 10.1158/0008-5472.can-23-2115
Abstract: Alveolar soft part sarcoma (ASPS) is a rare mesenchymal malignancy driven by the ASPSCR1::TFE3 fusion. A better understanding of the mechanisms by which this oncogenic transcriptional regulator drives cancer growth is needed to help identify… read more here.
Keywords: aspscr1 tfe3; part sarcoma; biology; alveolar soft ... See more keywords
Abstract A017: IGF2BP1 is essential for ETO2/GLIS2 leukemogenesis via stabilization of primitive myeloid transcriptional programs
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1538-8514.rnadrivers24-a017
Abstract: Certain subtypes of pediatric leukemia continue to have dismal cure rates despite advances in targeted therapy. One such disease is acute megakaryoblastic leukemia (AMKL) with a rearrangement of ETO2/GLIS2 (also known as CBFA2T3/GLIS2.) Based on… read more here.
Keywords: eto2 glis2; igf2bp1; glis2; transcriptional programs ... See more keywords
Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs for Multiple Myelioma Therapy
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125202
Abstract: c-Myc plays a pivotal role in multiple myeloma (MM) pathogenesis; and the BET protein BRD4 is a key regulator of c-Myc transcription. Recently, a pathophysiologic role in MM has also been attributed to the AP-1… read more here.
Keywords: transcriptional programs; protein levels; myc junb; junb ... See more keywords