Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before
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DOI: 10.1002/bies.201700062
Abstract: Alzheimer's disease (AD) is the most common form of dementia that gradually disrupts the brain network to impair memory, language and cognition. While the amyloid hypothesis remains the leading proposed mechanism to explain AD pathophysiology,… read more here.
Keywords: apoe boldly; regulation app; app apoe; transcriptional regulation ... See more keywords
ZNF191 alters DNA methylation and activates the PI3K‐AKT pathway in hepatoma cells via transcriptional regulation of DNMT1
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DOI: 10.1002/cam4.4535
Abstract: Alteration of DNA methylation is an important event in pathogenesis and progression of hepatocellular carcinoma (HCC). DNA methyltransferase (DNMT) 1, the foremost contributor in DNA methylation machinery, was revealed elevated in HCC and significantly correlates… read more here.
Keywords: methylation; dna methylation; transcriptional regulation; regulation dnmt1 ... See more keywords
Non‐coding RNA regulatory networks in post‐transcriptional regulation of VEGFA in cancer
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DOI: 10.1002/iub.2620
Abstract: The switch from the normal quiescent vasculature to angiogenesis in tumors is induced by a variety of growth factors, released from cancer and stromal cells upon oxygen and nutrients deprivation. Vascular endothelial growth factor A… read more here.
Keywords: expression; transcriptional regulation; post transcriptional; cancer ... See more keywords
Transcriptional regulation of bovine elongation of very long chain fatty acids protein 6 in lipid metabolism and adipocyte proliferation
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DOI: 10.1002/jcb.28667
Abstract: The elongation of very long chain fatty acids protein 6 (ELOVL6) gene encodes a key enzyme that plays a role in lipogenesis through the catalytic elongation of both saturated and monounsaturated fatty acids. Previous studies… read more here.
Keywords: adipocyte proliferation; fatty acids; proliferation; metabolism adipocyte ... See more keywords
Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective
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DOI: 10.1002/med.21886
Abstract: The key proteins involved in transcriptional regulation play convergent roles in cellular homeostasis, and their dysfunction mediates aberrant gene expressions that underline the hallmarks of tumorigenesis. As tumor progression is dependent on such abnormal regulation… read more here.
Keywords: targeting key; involved transcriptional; transcriptional regulation; regulation ... See more keywords
RNA mimicry in post‐transcriptional regulation by aminoacyl tRNA synthetases
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DOI: 10.1002/wrna.1564
Abstract: Aminoacyl tRNA synthetases (aaRS) are well studied for their roles in tRNA charging with cognate amino acid. Nevertheless, numerous lines of evidence indicate that these proteins have roles other than tRNA charging. These include coordination… read more here.
Keywords: transcriptional regulation; post transcriptional; trna synthetases; aminoacyl trna ... See more keywords
Post‐transcriptional regulation of polycistronic microRNAs
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DOI: 10.1002/wrna.1749
Abstract: An important proportion of microRNA (miRNA) genes tend to lie close to each other within animal genomes. Such genomic organization is generally referred to as miRNA clusters. Even though many miRNA clusters have been greatly… read more here.
Keywords: regulation polycistronic; mirna clusters; transcriptional regulation; post transcriptional ... See more keywords
Introduction to Bioinformatics Resources for Post-transcriptional Regulation of Gene Expression.
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DOI: 10.1007/978-1-0716-1851-6_1
Abstract: Untranslated regions of mRNA (UTRs) are involved in defining the fate of the transcript through processes such as mRNA localization, degradation, translation initiation regulation, and several others: the action of trans-factors such as RNA-binding proteins… read more here.
Keywords: introduction bioinformatics; post transcriptional; bioinformatics resources; resources post ... See more keywords
Transcriptional Regulation of T Cell Metabolism Reprograming.
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DOI: 10.1007/978-94-024-1170-6_3
Abstract: T cell activation, differentiation, and function are tightly regulated by a complex network of transcription factors, epigenetic modifications, and signaling pathways of both TCR and cytokines. Over the past decade, it is increasingly clear that… read more here.
Keywords: regulation cell; immune responses; cell immune; cell ... See more keywords
Transcriptional Regulation of DJ-1.
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DOI: 10.1007/978-981-10-6583-5_7
Abstract: DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the… read more here.
Keywords: transcription; binding protein; transcription factors; regulation ... See more keywords
Role of Zic Family Proteins in Transcriptional Regulation and Chromatin Remodeling.
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DOI: 10.1007/978-981-10-7311-3_18
Abstract: Proper functions of Zic proteins are essential for animals in health and disease. Here, we summarize our current understanding of the molecular properties and functions of the Zic family across animal species and paralog subtypes.… read more here.
Keywords: zic family; chromatin; zic proteins; zic ... See more keywords