Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental hematology"
DOI: 10.1016/j.exphem.2019.03.003
Abstract: Reduced expression of the transcription factor PU.1 is frequently associated with development of acute myeloid leukemia (AML), whereas elevated levels of CITED2 (CBP/p300-interacting-transactivator-with-an-ED-rich-tail 2) enhance maintenance of both normal and leukemic hematopoietic stem and progenitor… read more here.
Keywords: cooperate maintaining; transcriptional regulators; cited2 cooperate; hematopoietic stem ... See more keywords
Target acquired: transcriptional regulators as drug targets for protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2020.12.007
Abstract: Protozoan parasites are single-celled eukaryotic organisms that cause significant human disease and pose a substantial health and socioeconomic burden worldwide. They are responsible for at least 1 million deaths annually. The treatment of such diseases… read more here.
Keywords: drug targets; protozoan parasites; transcriptional regulators; target acquired ... See more keywords
A small RNA regulates pprM, a modulator of pleiotropic proteins promoting DNA repair, in Deinococcus radiodurans under ionizing radiation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-91335-8
Abstract: Networks of transcriptional and post-transcriptional regulators are critical for bacterial survival and adaptation to environmental stressors. While transcriptional regulators provide rapid activation and/or repression of a wide-network of genes, post-transcriptional regulators, such as small RNAs… read more here.
Keywords: post transcriptional; transcriptional regulators; dna repair; radiation ... See more keywords
AnnoMiner is a new web-tool to integrate epigenetics, transcription factor occupancy and transcriptomics data to predict transcriptional regulators
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94805-1
Abstract: Gene expression regulation requires precise transcriptional programs, led by transcription factors in combination with epigenetic events. Recent advances in epigenomic and transcriptomic techniques provided insight into different gene regulation mechanisms. However, to date it remains… read more here.
Keywords: transcription; transcriptional regulators; transcription factor; annominer ... See more keywords
Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society Transactions"
DOI: 10.1042/bst20170013
Abstract: Diverse neurodegenerative diseases share some common aspects to their pathology, with many showing evidence of disruption to the brain's numerous homeostatic processes. As such, imbalanced inflammatory status, glutamate dyshomeostasis, hypometabolism and oxidative stress are implicated… read more here.
Keywords: neurodegenerative disease; homeostatic processes; disease trajectory; transcriptional regulators ... See more keywords
The transcriptional co-regulators NBCL1 and NBCL2 redundantly coordinate aerial organ development and root nodule identity in legumes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac389
Abstract: Medicago truncatula NODULE ROOT1 (MtNOOT1) and Pisum sativum COCHLEATA1 (PsCOCH1) are orthologous genes belonging to the NOOT-BOP-COCH-LIKE (NBCL) gene family which encodes key transcriptional co-regulators of plant development. In Mtnoot1 and Pscoch1 mutants, the development… read more here.
Keywords: nodule; development; transcriptional regulators; nodule identity ... See more keywords
Machine learning from Pseudomonas aeruginosa transcriptomes identifies independently modulated sets of genes associated with known transcriptional regulators
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac187
Abstract: Abstract The transcriptional regulatory network (TRN) of Pseudomonas aeruginosa coordinates cellular processes in response to stimuli. We used 364 transcriptomes (281 publicly available + 83 in-house generated) to reconstruct the TRN of P. aeruginosa using… read more here.
Keywords: sets genes; pseudomonas aeruginosa; independently modulated; transcriptional regulators ... See more keywords
A new family of transcriptional regulators of tungstoenzymes and molybdate/tungstate transport
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Microbiology"
DOI: 10.1111/1462-2920.14500
Abstract: Bacterial genes for molybdenum-containing and tungsten-containing enzymes are often differentially regulated depending on the metal availability in the environment. Here, we describe a new family of transcription factors with an unusual DNA-binding domain related to… read more here.
Keywords: family transcriptional; molybdate tungstate; transcriptional regulators; family ... See more keywords
Developmental regulators moonlighting as transposons defense factors.
Sign Up to like & getrecommendations! Published in 2023 at "Andrology"
DOI: 10.1111/andr.13427
Abstract: BACKGROUND The germline perpetuates genetic information across generations. To maintain the integrity of the germline, transposable elements (TEs) in the genome must be silenced, as these mobile elements would otherwise engender widespread mutations passed on… read more here.
Keywords: regulators moonlighting; defense; transcriptional regulators; defense factors ... See more keywords
Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00226-20
Abstract: Successful colonization by enteric pathogens is contingent upon effective interactions with the host and the resident microbiota. These pathogens thus respond to and integrate myriad signals to control virulence. Long-chain fatty acids repress the virulence… read more here.
Keywords: arac type; transcriptional regulators; fatty acids; repress virulence ... See more keywords
Developmental disorders caused by haploinsufficiency of transcriptional regulators: a perspective based on cell fate determination
Sign Up to like & getrecommendations! Published in 2022 at "Biology Open"
DOI: 10.1242/bio.058896
Abstract: ABSTRACT Many human birth defects and neurodevelopmental disorders are caused by loss-of-function mutations in a single copy of transcription factor (TF) and chromatin regulator genes. Although this dosage sensitivity has long been known, how and… read more here.
Keywords: disorders caused; cell fate; transcriptional regulators; biology ... See more keywords