Transcriptional repression shapes the identity and function of tissue macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13269
Abstract: The changing extra- and intracellular microenvironment calls for rapid cell fate decisions that are precisely and primarily regulated at the transcriptional level. The cellular components of the immune system are excellent examples of how cells… read more here.
Keywords: tissue macrophages; tissue; function; identity ... See more keywords
Efficient Depletion of Fission Yeast Condensin by Combined Transcriptional Repression and Auxin-Induced Degradation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9520-2_3
Abstract: Structural maintenance of chromosomes (SMC) complexes play pivotal roles in controlling chromatin organization. Condensin is an essential SMC complex that compacts chromatin to form condensed chromosomes in mitosis. Complete condensin inactivation is necessary to reveal… read more here.
Keywords: repression auxin; condensin; depletion; fission yeast ... See more keywords
PTPN2 copper-sensing relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-50524-5
Abstract: Fluxes in human copper levels recently garnered attention for roles in cellular signaling, including affecting levels of the signaling molecule cyclic adenosine monophosphate. We herein apply an unbiased temporal evaluation of the signaling and whole… read more here.
Keywords: copper; level fluctuations; copper level; transcriptional repression ... See more keywords
Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2322066121
Abstract: Significance The Wnt signaling pathway, often deregulated in cancer and other diseases, remains poorly understood in lipid metabolism, particularly lipid mobilization. This study reveals that active Wnt/Wg signaling potently reduces lipid accumulation in Drosophila adipocytes… read more here.
Keywords: wnt; transcriptional repression; induced transcriptional; wnt signaling ... See more keywords
The chromatin remodeler RSF1 coordinates epigenetic marks for transcriptional repression and DSB repair
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1093
Abstract: Abstract DNA lesions impact on local transcription and the damage-induced transcriptional repression facilitates efficient DNA repair. However, how chromatin dynamics cooperates with these two events remained largely unknown. We here show that histone H2A acetylation… read more here.
Keywords: transcriptional repression; dna; h2a; repair ... See more keywords
Modeling single-cell phenotypes links yeast stress acclimation to transcriptional repression and pre-stress cellular states
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2021.09.08.459442
Abstract: Stress defense and cell growth are inversely related in bulk culture analyses; however, these studies miss substantial cell-to-cell heterogeneity, thus obscuring true phenotypic relationships. Here, we devised a microfluidics system to characterize multiple phenotypes in… read more here.
Keywords: stress; cell; growth; msn2 ... See more keywords
Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.277046.122
Abstract: GLP (EHMT1) is a multifunctional protein, best known for its role as an H3K9me1 and H3K9me2 methyltransferase through its reportedly obligatory dimerization with G9A (EHMT2). Here, we investigate the role of GLP in the oocyte… read more here.
Keywords: glp; g9a; glp cdko; cko ... See more keywords
Tyrosine 1–phosphorylated RNA polymerase II transcribes PROMPTs to facilitate proximal promoter pausing and induce global transcriptional repression in response to DNA damage
Sign Up to like & getrecommendations! Published in 2024 at "Genome Research"
DOI: 10.1101/gr.278644.123
Abstract: DNA damage triggers a complex transcriptional response that involves both activation and repression of gene expression. In this study, we investigated global changes in transcription in response to ionizing irradiation (IR), which induces double-strand breaks… read more here.
Keywords: dna damage; promoter pausing; transcriptional repression; response ... See more keywords
RAMOSA1 ENHANCER LOCUS2-Mediated Transcriptional Repression Regulates Vegetative and Reproductive Architecture1[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Physiology"
DOI: 10.1104/pp.18.00913
Abstract: Genetic and molecular analysis of the maize REL2 transcriptional corepressor defines a function for the WD40 domain of TOPLESS proteins and reveals a major role for REL2 in meristem development. Transcriptional repression in multicellular organisms… read more here.
Keywords: vegetative reproductive; enhancer locus2; repression; ramosa1 enhancer ... See more keywords
Histone Deacetylases SRT1 and SRT2 Interact with ENAP1 to Mediate Ethylene-Induced Transcriptional Repression[OPEN]
Sign Up to like & getrecommendations! Published in 2018 at "Plant Cell"
DOI: 10.1105/tpc.17.00671
Abstract: Histone deacetylases STR1 and SRT2 interact with ENAP1, mediating transcriptional repression by regulating the levels of H3K9Ac in the ethylene response. Ethylene plays pleiotropic roles in plant growth, plant development, and stress responses. Although the… read more here.
Keywords: ethylene; srt1 srt2; histone deacetylases; srt2 interact ... See more keywords
Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
Sign Up to like & getrecommendations! Published in 2024 at "Genome Biology"
DOI: 10.1186/s13059-024-03209-7
Abstract: Bromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in fungi. BP1 recognizes trimethylation of lysine 27 in histone H3 (H3K27me3), an epigenetic hallmark of gene silencing. However, whether… read more here.
Keywords: liquid phase; bp1; transcriptional repression; phase separation ... See more keywords