The transcriptional signature associated with human motile cilia
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DOI: 10.1038/s41598-020-66453-4
Abstract: Cilia are complex microtubule-based organelles essential to a range of processes associated with embryogenesis and tissue homeostasis. Mutations in components of these organelles or those involved in their assembly may result in a diverse set… read more here.
Keywords: motile cilia; signature; transcriptional signature; cilia associated ... See more keywords
PD‐1‐induced proliferating T cells exhibit a distinct transcriptional signature
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DOI: 10.1111/imm.13388
Abstract: Ligation of the inhibitory receptor PD‐1 on T cells results in the inhibition of numerous cellular functions. Despite the overtly inhibitory outcome of PD‐1 signalling, there are additionally a collection of functions that are activated.… read more here.
Keywords: distinct transcriptional; induced proliferating; exhibit distinct; proliferating cells ... See more keywords
Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans
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DOI: 10.1161/atvbaha.121.315896
Abstract: Supplemental Digital Content is available in the text. Objective: Accelerated atherosclerosis in diabetes constitutes an ongoing challenge despite optimal medical therapies. This study aimed to identify evolutionarily conserved lesion-based regulatory signaling networks in diabetic versus… read more here.
Keywords: atherosclerosis; transcriptional signature; signaling pathways; lesional transcriptional ... See more keywords
An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes.
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DOI: 10.2337/db22-0521
Abstract: Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study… read more here.
Keywords: early islet; autoimmune diabetes; transcriptional signature; islet transcriptional ... See more keywords
A Qualitative Transcriptional Signature for the Risk Assessment of Precancerous Colorectal Lesions
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DOI: 10.3389/fgene.2020.573787
Abstract: It is meaningful to assess the risk of cancer incidence among patients with precancerous colorectal lesions. Comparing the within-sample relative expression orderings (REOs) of colorectal cancer patients measured by multiple platforms with that of normal… read more here.
Keywords: incidence; risk; qualitative transcriptional; colorectal lesions ... See more keywords
Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01679
Abstract: Inducing T cell responses by therapeutic vaccination requires appropriate activation of antigen presenting cells (APCs). The use of virus-like particles (VLPs) containing Toll-like receptor (TLR) ligands has demonstrated remarkable potential in activating APCs and modulating… read more here.
Keywords: tlr ligands; cell responses; cell; vlps containing ... See more keywords