Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4a0219-050r
Abstract: The host immune response is characterized by a complex interplay of signal‐specific cellular transcriptional responses. The magnitude of the immune response is dependent on the strength of the external stimulus. Knowledge on leukocyte transcriptional responses… read more here.
Keywords: leukocyte transcriptional; lps dose; signatures dependent; lps dosage ... See more keywords
Transcriptional Signatures of Tau and Amyloid Neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Cell Reports"
DOI: 10.1016/j.celrep.2020.01.063
Abstract: Summary Alzheimer’s disease (AD) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. We use transgenic mice harboring human tau (rTg4510) and amyloid precursor protein (J20) mutations… read more here.
Keywords: transcriptional signatures; signatures tau; neuropathology; pathology ... See more keywords
Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.08.002
Abstract: The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here,… read more here.
Keywords: cellular states; transcriptional signatures; generate maps; decomposing oncogenic ... See more keywords
Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09990-5
Abstract: Changes in bulk transcriptional profiles of heterogeneous samples often reflect changes in proportions of individual cell types. Several robust techniques have been developed to dissect the composition of such mixed samples given transcriptional signatures of… read more here.
Keywords: transcriptional signatures; complete deconvolution; cellular mixtures; deconvolution cellular ... See more keywords
PATH-63. TRANSCRIPTIONAL SIGNATURES IN HISTOLOGIC STRUCTURES WITHIN GLIOBLASTOMA TUMORS MAY PREDICT PERSONALIZED TREATMENT SENSITIVITY AND SURVIVAL
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.658
Abstract: Personalized treatment strategies in Glioblastoma multiforme (GBM) has been hampered by intra-tumoral heterogeneity. The goals of this study were to (1) determine the impact of intra-tumoral heterogeneity on established predictive and prognostic transcriptional signatures in… read more here.
Keywords: transcriptional signatures; gbm; tumors may; personalized treatment ... See more keywords
Isoniazid preventive therapy and tuberculosis transcriptional signatures in people with HIV
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003262
Abstract: Objective(s): To examine the association between isoniazid preventive therapy (IPT) or nontuberculous mycobacteria (NTM) sputum culture positivity and tuberculosis (TB) transcriptional signatures in people with HIV. Design: Cross-sectional study. Methods: We enrolled adults living with… read more here.
Keywords: transcriptional signatures; people hiv; therapy; preventive therapy ... See more keywords
S110 Concise whole blood transcriptional signatures for incipient tuberculosis: a systematic review and individual participant data meta-analysis
Sign Up to like & getrecommendations! Published in 2019 at "Thorax"
DOI: 10.1136/thorax-2019-btsabstracts2019.116
Abstract: Background Blood transcriptional signatures may predict risk of tuberculosis (TB). While multiple candidate signatures for active and incipient TB have been identified, it is not known which signature performs best, or whether any meets World… read more here.
Keywords: participant data; blood transcriptional; systematic review; signatures incipient ... See more keywords
Transcriptional signatures throughout development: the effects of mouse embryo manipulation in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Reproduction"
DOI: 10.1530/rep-16-0473
Abstract: Stressful environmental exposures incurred early in development can affect postnatal metabolic health and susceptibility to non-communicable diseases in adulthood, although the molecular mechanisms by which this occurs have yet to be elucidated. Here we use… read more here.
Keywords: transcriptional signatures; throughout development; embryo manipulation; signatures throughout ... See more keywords
Comparison of Transcriptional Signatures of Three Staphylococcal Superantigenic Toxins in Human Melanocytes
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061402
Abstract: Staphylococcus aureus, a gram-positive bacterium, causes toxic shock through the production of superantigenic toxins (sAgs) known as Staphylococcal enterotoxins (SE), serotypes A-J (SEA, SEB, etc.), and toxic shock syndrome toxin-1 (TSST-1). The chronology of host… read more here.
Keywords: transcriptional signatures; signatures three; comparison transcriptional; three staphylococcal ... See more keywords