A09 Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Therapeutic Vulnerabilities in Lung Cancer
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DOI: 10.1016/j.jtho.2019.12.038
Abstract: KRASG12C(ON) inhibitors with agents targeting pathway nodes both upand downstream of RAS, as well as other parallel pathways, can drive combination benefit in distinct cancer histotypes. Tri-complex inhibitors that target the active, GTP-bound form of… read more here.
Keywords: cancer; subtypes resolve; transcriptional subtypes; a09 transcriptional ... See more keywords
A simplified integrated molecular and immunohistochemistry-based algorithm allows high accuracy prediction of glioblastoma transcriptional subtypes
Sign Up to like & getrecommendations! Published in 2020 at "Laboratory Investigation"
DOI: 10.1038/s41374-020-0437-0
Abstract: Glioblastomas (GBM) can be classified into three major transcriptional subgroups (proneural, mesenchymal, classical), underlying different molecular alterations, prognosis, and response to therapy. However, transcriptional analysis is not routinely feasible and assessment of a simplified method… read more here.
Keywords: classification; transcriptional subtypes; glioblastoma transcriptional; high accuracy ... See more keywords