Meiotic commitment: More than a transcriptional switch
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.1016/j.cub.2022.02.064
Abstract: Commitment to cellular differentiation programs can be controlled by self-activating transcription factors that trigger the expression of cell-type-specific genes. A new study shows that, although commitment to meiosis in yeast is controlled in this manner,… read more here.
Keywords: commitment transcriptional; biology; commitment; meiotic commitment ... See more keywords
A Temporal Transcriptional Switch Governs Stem Cell Division, Neuronal Numbers, and Maintenance of Differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.02.023
Abstract: The importance of producing the correct numbers of neurons during development is illustrated by both evolutionary enhancement of cognitive capacities in larger brains, and developmental disorders of brain size. In humans, increased neuronal numbers during development is… read more here.
Keywords: neuronal numbers; cell division; transcriptional switch; stem cell ... See more keywords
Reprogramming the Metabolic Network in Kluyveromyces lactis with a Transcriptional Switch for De Novo Lacto-N-biose Synthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c01779
Abstract: Lacto-N-biose (LNB) is a member of the human milk oligosaccharide (HMO) family and is synthesized via an enzymatic reaction in vitro with N-acetylglucosamine (GlcNAc) and cofactors. In this study, LNB was synthesized using a cell… read more here.
Keywords: metabolic network; kluyveromyces lactis; transcriptional switch; lacto biose ... See more keywords
A transcriptional switch governs fibroblast activation in heart disease.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03674-1
Abstract: In diseased organs, stress-activated signalling cascades alter chromatin, thereby triggering maladaptive cell state transitions. Fibroblast activation is a common stress response in tissues that worsens lung, liver, kidney and heart disease, yet its mechanistic basis remains… read more here.
Keywords: heart disease; transcriptional switch; activation; cell ... See more keywords
A transcriptional switch controls meiosis
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.31911
Abstract: A key protein involved in the segregation of meiotic chromosomes is produced 'just in time' by the regulated expression of two mRNA isoforms. read more here.
Keywords: transcriptional switch; controls meiosis; switch controls;