Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-0967-3
Abstract: Genomic amplification of the oncogene MYCN is a major driver in the development of high-risk neuroblastoma, a pediatric cancer with poor prognosis. Given the challenge in targeting MYCN directly for therapy, we sought to identify… read more here.
Keywords: gldc; transcriptional target; mycn; proliferation ... See more keywords
Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac360
Abstract: Abstract The aryl hydrocarbon receptor (AHR) regulates the expression of numerous genes in response to activation by agonists including xenobiotics. Although it is well appreciated that environmental signals and cell intrinsic features may modulate this… read more here.
Keywords: ahr signalling; hexokinase transcriptional; transcriptional target; modulator ... See more keywords
SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27030811
Abstract: CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression… read more here.
Keywords: cell; cd44; transcriptional target; progression ... See more keywords
Characterization of DAPK1 as a novel transcriptional target of BRMS1.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.3930
Abstract: Breast cancer metastasis suppressor 1 (BRMS1) can specifically regulate tumor metastasis in many cancers. Our previous studies have demonstrated that BRMS1 can promote cell apoptosis through regulating osteopontin (OPN) expression in hepatocellular carcinoma (HCC) cells.… read more here.
Keywords: brms1; transcriptional target; target brms1; expression ... See more keywords