The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2021.12.038
Abstract: The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation.… read more here.
Keywords: hiv infected; transcriptionally active; hiv; cells survive ... See more keywords
Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles
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DOI: 10.1016/j.csbj.2019.07.019
Abstract: Rotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription… read more here.
Keywords: rotavirus; transcriptionally active; dlps; reveals architectural ... See more keywords
Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity
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DOI: 10.1128/mbio.03256-21
Abstract: HIV-1 integrates its genomic DNA into the chromosomes of the infected cell, but how it selects the site of integration and the impact of their location in the 3-dimensional nuclear space is not well understood.… read more here.
Keywords: integration; transcriptionally active; cell; activity ... See more keywords
Viral infectious diseases severity: co-presence of transcriptionally active microbes (TAMs) can play an integral role for disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1056036
Abstract: Humans have been challenged by infectious diseases for all of their recorded history, and are continually being affected even today. Next-generation sequencing (NGS) has enabled identification of, i) culture independent microbes, ii) emerging disease-causing pathogens,… read more here.
Keywords: active microbes; transcriptionally active; infectious diseases; presence ... See more keywords