Identification of transcriptionallyâactive human papillomavirus integrants through nanopore sequencing reveals viable targets for gene therapy against cervical cancer
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29769
Abstract: Integration of the human papillomavirus (HPV) genome into the cellular genome is a key event that leads to constitutive expression of viral oncoprotein E6/E7 and drives the progression of cervical cancer. However, HPV integration patterns… read more here.
Keywords: hpv; transcriptionally active; human papillomavirus; cervical cancer ... See more keywords
The loud minority: Transcriptionally active HIV-1-infected cells survive, proliferate, and persist
Sign Up to like & getrecommendations! Published in 2022 at "Cell"
DOI: 10.1016/j.cell.2021.12.038
Abstract: The shock-and-kill strategy reactivates HIV-1 latent reservoir for immune clearance. Einkauf et al. found that some HIV-1-infected cells that persist and proliferate have transcriptionally active HIV-1 in permissive chromatin. Silent proviruses in repressive chromatin resist reactivation.… read more here.
Keywords: hiv infected; transcriptionally active; hiv; cells survive ... See more keywords
Cryo-EM Reveals Architectural Diversity in Active Rotavirus Particles
Sign Up to like & getrecommendations! Published in 2019 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2019.07.019
Abstract: Rotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription… read more here.
Keywords: rotavirus; transcriptionally active; dlps; reveals architectural ... See more keywords
Intranuclear Positions of HIV-1 Proviruses Are Dynamic and Do Not Correlate with Transcriptional Activity
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03256-21
Abstract: HIV-1 integrates its genomic DNA into the chromosomes of the infected cell, but how it selects the site of integration and the impact of their location in the 3-dimensional nuclear space is not well understood.… read more here.
Keywords: integration; transcriptionally active; cell; activity ... See more keywords
Viral infectious diseases severity: co-presence of transcriptionally active microbes (TAMs) can play an integral role for disease severity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1056036
Abstract: Humans have been challenged by infectious diseases for all of their recorded history, and are continually being affected even today. Next-generation sequencing (NGS) has enabled identification of, i) culture independent microbes, ii) emerging disease-causing pathogens,… read more here.
Keywords: active microbes; transcriptionally active; infectious diseases; presence ... See more keywords
Molecular detection of transcriptionally active ovine papillomaviruses in commercial equine semen
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2024.1427370
Abstract: Virological evaluation was performed on equine semen to detect the presence of papillomaviruses (PVs) using droplet digital polymerase chain reaction (ddPCR) as the aim of this study was to investigate whether the sperm from asymptomatic… read more here.
Keywords: equine semen; transcriptionally active; semen samples; ovine papillomaviruses ... See more keywords