Integrating transcriptomic datasets across neurological disease identifies unique myeloid subpopulations driving disease‐specific signatures
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DOI: 10.1002/glia.24314
Abstract: Microglia and bone marrow‐derived monocytes are key elements of central nervous system (CNS) inflammation, both capable of enhancing and dampening immune‐mediated pathology. However, the study‐specific focus on individual cell types, disease models or experimental approaches… read more here.
Keywords: transcriptomic datasets; disease; disease specific; pathology ... See more keywords
Assessing reproducibility of matrix factorization methods in independent transcriptomes
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DOI: 10.1093/bioinformatics/btz225
Abstract: Abstract Motivation Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on the between-datasets… read more here.
Keywords: factorization methods; reproducibility; matrix factorization; transcriptomic datasets ... See more keywords
A Strategy for the Selection of RT-qPCR Reference Genes Based on Publicly Available Transcriptomic Datasets
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DOI: 10.3390/biomedicines11041079
Abstract: In the next-generation sequencing era, RT-qPCR is still widely employed to quantify levels of nucleic acids of interest due to its popularity, versatility, and limited costs. The measurement of transcriptional levels through RT-qPCR critically depends… read more here.
Keywords: transcriptomic datasets; reference; strategy; available transcriptomic ... See more keywords