Transcriptomic and genomic variants between koala populations reveals underlying genetic components to disorders in a bottlenecked population
Sign Up to like & getrecommendations! Published in 2021 at "Conservation Genetics"
DOI: 10.1007/s10592-021-01340-7
Abstract: Historical hunting pressures on koalas in the southern part of their range in Australia have led to a marked genetic bottleneck when compared with their northern counterparts. There are a range of suspected genetic disorders… read more here.
Keywords: genomic variants; population; variants koala; two populations ... See more keywords
Single-cell transcriptomic and genomic changes in the ageing human brain
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DOI: 10.1038/s41586-025-09435-8
Abstract: Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process1. In the human brain, the prefrontal cortex undergoes age-related changes that can affect cognitive functioning later in… read more here.
Keywords: brain; single cell; human brain; transcriptomic genomic ... See more keywords
Integrated transcriptomic–genomic tool Texomer profiles cancer tissues
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DOI: 10.1038/s41592-019-0388-9
Abstract: Profiling of both the genome and the transcriptome promises a comprehensive, functional readout of a tissue sample, yet analytical approaches are required to translate the increased data dimensionality, heterogeneity and complexity into patient benefits. We… read more here.
Keywords: transcriptomic genomic; tool texomer; genomic tool; texomer ... See more keywords
Transcriptomic and genomic characteristics of intrahepatic metastases of primary liver cancer
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DOI: 10.1186/s12885-024-12428-x
Abstract: Patients with primary multifocal hepatocellular carcinoma (HCC) have a poor prognosis and often experience a high rate of treatment failure. Multifocal HCC is mainly caused by intrahepatic metastasis (IM), and though portal vein tumor thrombosis… read more here.
Keywords: pro meta; transcriptomic genomic; hcc; cancer transcriptomic ... See more keywords
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels
Sign Up to like & getrecommendations! Published in 2024 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-024-01790-3
Abstract: Glioblastoma (GBM) is the most common malignant brain tumor in adults, which remains incurable and often recurs rapidly after initial therapy. While large efforts have been dedicated to uncover genomic/transcriptomic alternations associated with the recurrence… read more here.
Keywords: transcriptomic genomic; differences paired; wild type; idh ... See more keywords