Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202249815
Abstract: The immune reconstitution inflammatory syndrome (IRIS) can be a complication of anti-retroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial… read more here.
Keywords: reconstitution inflammatory; hiv; immune reconstitution; inflammatory syndrome ... See more keywords
Identification of transcriptomic signatures and crucial pathways involved in non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02716-y
Abstract: Our study aimed to uncover the crucial genes and functional pathways involved in the development of non-alcoholic steatohepatitis (NASH). Liver transcriptome datasets were integrated with Robust rank aggregation (RRA) method, and transcriptomic signatures for NASH… read more here.
Keywords: fibrosis; non alcoholic; alcoholic steatohepatitis; transcriptomic signatures ... See more keywords
Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101315
Abstract: Highlights • Most patient with pancreatic cancer are treated by chemotherapy.• Treatments selection are not personalized on the tumor characteristics.• Signatures predicting chemotherapy efficiency are essential for personalizing treatments.• An RNA signature of gemcitabine-sensitivity is… read more here.
Keywords: relevance biopsy; efficient transcriptomic; transcriptomic signatures; biopsy derived ... See more keywords
Divergent transcriptomic signatures from putative mesenchymal stimuli in glioblastoma cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-023-00724-w
Abstract: In glioblastoma, a mesenchymal phenotype is associated with especially poor patient outcomes. Various glioblastoma microenvironmental factors and therapeutic interventions are purported drivers of the mesenchymal transition, but the degree to which these cues promote the… read more here.
Keywords: transcriptomic signatures; putative mesenchymal; divergent transcriptomic; mesenchymal transitions ... See more keywords
Cross-species transcriptomic signatures identify mechanisms related to species sensitivity and common responses to nanomaterials
Sign Up to like & getrecommendations! Published in 2022 at "Nature Nanotechnology"
DOI: 10.1038/s41565-022-01096-2
Abstract: Physico-chemical characteristics of engineered nanomaterials are known to be important in determining the impact on organisms but effects are equally dependent upon the characteristics of the organism exposed. Species sensitivity may vary by orders of… read more here.
Keywords: signatures identify; sensitivity; species sensitivity; transcriptomic signatures ... See more keywords
Abstract 3169: Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures in melanoma enhances immunotherapy response prediction
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3169
Abstract: Background: Cytotoxic T lymphocytes (CTL) play a crucial role in anti-cancer immunity. Progression of CTL to exhausted T lymphocytes (ETL) that overexpress inhibitory receptors can substantially decrease effector cytokines production and diminish cytolytic activity in… read more here.
Keywords: cytotoxic; transcriptomic signatures; correlation; response ... See more keywords
Abstract 4660: Epstein-Barr virus transcriptomic signatures of tumor subpopulations predict relapse in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4660
Abstract: Nasopharyngeal carcinoma (NPC), originating from nasopharyngeal epithelium and frequently metastasizes to cervical lymph nodes and distal organs, is endemic in Southeast Asia and highly associated with Epstein-Barr virus (EBV). Radiation therapy with or without concurrent… read more here.
Keywords: relapse; transcriptomic signatures; epstein barr; nasopharyngeal carcinoma ... See more keywords
Abstract 131: Intracranial and Femoral Whole Blood Display Distinct Transcriptomic Signatures
Sign Up to like & getrecommendations! Published in 2025 at "Stroke"
DOI: 10.1161/str.56.suppl_1.131
Abstract: Introduction: Vein of Galen malformations (VOGM) are embryonic choroid plexus-derived arteriovenous malformations which may develop secondary to mosaicism. Sequencing of peripheral whole blood is often ineffective in identifying novel mutations responsible for VOGM development. Whole… read more here.
Keywords: blood; choroid plexus; transcriptomic signatures; whole blood ... See more keywords
Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201807-1419oc
Abstract: Rationale: There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis response signatures (SRSs) have been identified. SRS1 is relatively immunosuppressed,… read more here.
Keywords: signatures sepsis; response; septic shock; shock ... See more keywords
Minimalistic transcriptomic signatures permit accurate early prediction of COVID-19 mortality
Sign Up to like & getrecommendations! Published in 2025 at "JCI Insight"
DOI: 10.1172/jci.insight.195436
Abstract: BACKGROUND Accurate prognostic assays for COVID-19 represent an unmet clinical need. We sought to identify and validate early parsimonious transcriptomic signatures that accurately predict fatal outcomes. METHODS We studied 894 patients enrolled in the prospective,… read more here.
Keywords: peripheral blood; transcriptomic signatures; covid; mortality ... See more keywords
Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1157-7
Abstract: BackgroundComparative transcriptomics can answer many questions in developmental and evolutionary developmental biology. Most transcriptomic studies start by showing global patterns of variation in transcriptomes that differ between species or organs through developmental time. However, little… read more here.
Keywords: developmental biology; biology; transcriptomic signatures; biology transcriptomic ... See more keywords