Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202249815
Abstract: The immune reconstitution inflammatory syndrome (IRIS) can be a complication of anti-retroviral therapy (ART) in patients with advanced HIV, but its pathogenesis is uncertain. In tuberculosis (TB) endemic countries, IRIS is often associated with mycobacterial… read more here.
Keywords: reconstitution inflammatory; hiv; immune reconstitution; inflammatory syndrome ... See more keywords
Identification of transcriptomic signatures and crucial pathways involved in non-alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2021 at "Endocrine"
DOI: 10.1007/s12020-021-02716-y
Abstract: Our study aimed to uncover the crucial genes and functional pathways involved in the development of non-alcoholic steatohepatitis (NASH). Liver transcriptome datasets were integrated with Robust rank aggregation (RRA) method, and transcriptomic signatures for NASH… read more here.
Keywords: fibrosis; non alcoholic; alcoholic steatohepatitis; transcriptomic signatures ... See more keywords
Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101315
Abstract: Highlights • Most patient with pancreatic cancer are treated by chemotherapy.• Treatments selection are not personalized on the tumor characteristics.• Signatures predicting chemotherapy efficiency are essential for personalizing treatments.• An RNA signature of gemcitabine-sensitivity is… read more here.
Keywords: relevance biopsy; efficient transcriptomic; transcriptomic signatures; biopsy derived ... See more keywords
Cross-species transcriptomic signatures identify mechanisms related to species sensitivity and common responses to nanomaterials
Sign Up to like & getrecommendations! Published in 2022 at "Nature Nanotechnology"
DOI: 10.1038/s41565-022-01096-2
Abstract: Physico-chemical characteristics of engineered nanomaterials are known to be important in determining the impact on organisms but effects are equally dependent upon the characteristics of the organism exposed. Species sensitivity may vary by orders of… read more here.
Keywords: signatures identify; sensitivity; species sensitivity; transcriptomic signatures ... See more keywords
Abstract 3169: Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures in melanoma enhances immunotherapy response prediction
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3169
Abstract: Background: Cytotoxic T lymphocytes (CTL) play a crucial role in anti-cancer immunity. Progression of CTL to exhausted T lymphocytes (ETL) that overexpress inhibitory receptors can substantially decrease effector cytokines production and diminish cytolytic activity in… read more here.
Keywords: cytotoxic; transcriptomic signatures; correlation; response ... See more keywords
Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.201807-1419oc
Abstract: Rationale: There remains uncertainty about the role of corticosteroids in sepsis with clear beneficial effects on shock duration, but conflicting survival effects. Two transcriptomic sepsis response signatures (SRSs) have been identified. SRS1 is relatively immunosuppressed,… read more here.
Keywords: signatures sepsis; response; septic shock; shock ... See more keywords
Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1157-7
Abstract: BackgroundComparative transcriptomics can answer many questions in developmental and evolutionary developmental biology. Most transcriptomic studies start by showing global patterns of variation in transcriptomes that differ between species or organs through developmental time. However, little… read more here.
Keywords: developmental biology; biology; transcriptomic signatures; biology transcriptomic ... See more keywords
Host transcriptomic signatures associated with dysbiosis in a preclinical model of lung cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.3107
Abstract: 3107 Background: Enrichment of the lower airway microbiota with oral commensals has been associated with transcriptomic changes affecting several inflammatory pathways associated with non-small cell lung cancer (NSCLC) development and progression. Using a mouse model… read more here.
Keywords: dysbiosis; lung cancer; cancer; lower airway ... See more keywords
Systematic review of diagnostic and prognostic host blood transcriptomic signatures of tuberculosis disease in people living with HIV
Sign Up to like & getrecommendations! Published in 2023 at "Gates Open Research"
DOI: 10.12688/gatesopenres.14327.2
Abstract: Background HIV-associated tuberculosis (TB) has high mortality; however, current triage and prognostic tools offer poor sensitivity and specificity, respectively. We conducted a systematic review of diagnostic and prognostic host-blood transcriptomic signatures of TB in people… read more here.
Keywords: host blood; blood transcriptomic; transcriptomic signatures; systematic review ... See more keywords
Transcriptomic signatures in colorectal cancer progression.
Sign Up to like & getrecommendations! Published in 2022 at "Current molecular medicine"
DOI: 10.2174/1566524022666220427102048
Abstract: AIMS Due to a large number of identified hub-genes, encoding key molecular regulators, which involve in signal transduction and metabolic pathways in cancers, it is relevant to systemize and update these findings. BACKGROUND Colorectal cancer… read more here.
Keywords: hub genes; progression; signatures colorectal; transcriptomic signatures ... See more keywords
Transcriptomic Signatures of Experimental Alkaloid Consumption in a Poison Frog
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10100733
Abstract: In the anuran family Dendrobatidae, aposematic species obtain their toxic or unpalatable alkaloids from dietary sources, a process known as sequestering. To understand how toxicity evolved in this family, it is paramount to elucidate the… read more here.
Keywords: experimental alkaloid; signatures experimental; consumption poison; alkaloid consumption ... See more keywords