Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.09.017
Abstract: Summary RNA sequencing analyses are often limited to identifying lowest p value transcripts, which does not address polygenic phenomena. To overcome this limitation, we developed an integrative approach that combines large-scale transcriptomic meta-analysis of patient… read more here.
Keywords: schizophrenia bipolar; transcriptomics reveals; reveals sexually; bipolar disorder ... See more keywords
Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.10.495613
Abstract: The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity… read more here.
Keywords: cell; cell transcriptomics; brain; reveals functionally ... See more keywords
Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.10.21.513224
Abstract: The central amygdala (CeA) consists of numerous genetically-defined inhibitory neurons that control defensive and appetitive behaviors including feeding. Transcriptomic signatures of cell types and their links to function remain poorly understood. Using single-nucleus RNA-sequencing, we… read more here.
Keywords: reveals amygdala; cea neurons; fasting ghrelin; appetitive cea ... See more keywords
Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans
Sign Up to like & getrecommendations! Published in 2021 at "BMC Biology"
DOI: 10.1186/s12915-021-01007-2
Abstract: Background Apicomplexa is a diverse phylum comprising unicellular endobiotic animal parasites and contains some of the most well-studied microbial eukaryotes including the devastating human pathogens Plasmodium falciparum and Cryptosporidium hominis . In contrast, data on… read more here.
Keywords: single cell; reveals differential; gregarine single; cell transcriptomics ... See more keywords
Single-cell transcriptomics reveals specific RNA editing signatures in the human brain.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.058271.116
Abstract: While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the… read more here.
Keywords: single cell; cell transcriptomics; rna editing; transcriptomics reveals ... See more keywords
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Sign Up to like & getrecommendations! Published in 2018 at "EMBO Reports"
DOI: 10.15252/embr.201846171
Abstract: Microglia are specialized parenchymal‐resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes… read more here.
Keywords: single cell; reveals distinct; distinct inflammation; cell transcriptomics ... See more keywords
Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202115653
Abstract: Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin‐derived irradiated cells with… read more here.
Keywords: ccr6; cell; cell transcriptomics; single cell ... See more keywords
Urinary transcriptomics reveals patterns associated with subclinical injury of the renal allograft.
Sign Up to like & getrecommendations! Published in 2018 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2017-0330
Abstract: AIM Subclinical pathological features in renal allograft biopsies predict poor outcomes, and noninvasive biomarkers are wanted. RNA quantification in urine predicts overt rejection. We hypothesized that a whole transcriptome analysis would be informative, even for… read more here.
Keywords: allograft; urinary transcriptomics; transcriptomics reveals; renal allograft ... See more keywords
Full-Length Spatial Transcriptomics Reveals the Unexplored Isoform Diversity of the Myocardium Post-MI
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.912572
Abstract: We introduce Single-cell Nanopore Spatial Transcriptomics (scNaST), a software suite to facilitate the analysis of spatial gene expression from second- and third-generation sequencing, allowing to generate a full-length near-single-cell transcriptional landscape of the tissue microenvironment.… read more here.
Keywords: full length; length spatial; single cell; spatial transcriptomics ... See more keywords
Hepatic Transcriptomics Reveals Reduced Lipogenesis in High-Salt Diet Mice
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14050966
Abstract: It has been demonstrated that a high salt diet (HSD) increases the risk of cardiovascular disease and metabolic dysfunction. In particular, the impact and molecular mechanisms of long-term HSD on hepatic metabolism remain largely unknown.… read more here.
Keywords: reveals reduced; high salt; hepatic transcriptomics; salt diet ... See more keywords
Comparative Transcriptomics Reveals the Molecular Mechanism of the Parental Lines of Maize Hybrid An’nong876 in Response to Salt Stress
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095231
Abstract: Maize (Zea mays L.) is an essential food crop worldwide, but it is highly susceptible to salt stress, especially at the seedling stage. In this study, we conducted physiological and comparative transcriptome analyses of seedlings… read more here.
Keywords: cm37 salt; comparative transcriptomics; salt stress; transcriptomics reveals ... See more keywords