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   Articles with "transcriptomics reveals" as a keyword



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Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder

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recommendations! Published in 2019 at "Cell Reports"

DOI: 10.1016/j.celrep.2019.09.017

Abstract: Summary RNA sequencing analyses are often limited to identifying lowest p value transcripts, which does not address polygenic phenomena. To overcome this limitation, we developed an integrative approach that combines large-scale transcriptomic meta-analysis of patient… read more here.

Keywords: schizophrenia bipolar; transcriptomics reveals; reveals sexually; bipolar disorder ... See more keywords

Spatial transcriptomics reveals regionally altered gene expression that drives retinal degeneration

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-07887-2

Abstract: Photoreceptor cell death is a hallmark of age-related macular degeneration. Environmental, lifestyle and genetic risk factors are known contributors to disease progression, whilst at the molecular level, oxidative stress and inflammation are central pathogenetic drivers.… read more here.

Keywords: spatial transcriptomics; gene expression; stress; oxidative stress ... See more keywords

Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain

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recommendations! Published in 2022 at "eLife"

DOI: 10.1101/2022.06.10.495613

Abstract: The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity… read more here.

Keywords: cell; cell transcriptomics; brain; reveals functionally ... See more keywords

Transcriptomics reveals amygdala neuron regulation by fasting and ghrelin thereby promoting feeding

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1101/2022.10.21.513224

Abstract: The central amygdala (CeA) consists of numerous genetically-defined inhibitory neurons that control defensive and appetitive behaviors including feeding. Transcriptomic signatures of cell types and their links to function remain poorly understood. Using single-nucleus RNA-sequencing, we… read more here.

Keywords: reveals amygdala; cea neurons; fasting ghrelin; appetitive cea ... See more keywords
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Gregarine single-cell transcriptomics reveals differential mitochondrial remodeling and adaptation in apicomplexans

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recommendations! Published in 2021 at "BMC Biology"

DOI: 10.1186/s12915-021-01007-2

Abstract: Background Apicomplexa is a diverse phylum comprising unicellular endobiotic animal parasites and contains some of the most well-studied microbial eukaryotes including the devastating human pathogens Plasmodium falciparum and Cryptosporidium hominis . In contrast, data on… read more here.

Keywords: single cell; reveals differential; gregarine single; cell transcriptomics ... See more keywords
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Single-cell transcriptomics reveals specific RNA editing signatures in the human brain.

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recommendations! Published in 2017 at "RNA"

DOI: 10.1261/rna.058271.116

Abstract: While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the… read more here.

Keywords: single cell; cell transcriptomics; rna editing; transcriptomics reveals ... See more keywords
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Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

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recommendations! Published in 2018 at "EMBO Reports"

DOI: 10.15252/embr.201846171

Abstract: Microglia are specialized parenchymal‐resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes… read more here.

Keywords: single cell; reveals distinct; distinct inflammation; cell transcriptomics ... See more keywords

Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis

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recommendations! Published in 2022 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.202115653

Abstract: Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin‐derived irradiated cells with… read more here.

Keywords: ccr6; cell; cell transcriptomics; single cell ... See more keywords
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Urinary transcriptomics reveals patterns associated with subclinical injury of the renal allograft.

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recommendations! Published in 2018 at "Biomarkers in medicine"

DOI: 10.2217/bmm-2017-0330

Abstract: AIM Subclinical pathological features in renal allograft biopsies predict poor outcomes, and noninvasive biomarkers are wanted. RNA quantification in urine predicts overt rejection. We hypothesized that a whole transcriptome analysis would be informative, even for… read more here.

Keywords: allograft; urinary transcriptomics; transcriptomics reveals; renal allograft ... See more keywords

Full-Length Spatial Transcriptomics Reveals the Unexplored Isoform Diversity of the Myocardium Post-MI

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.912572

Abstract: We introduce Single-cell Nanopore Spatial Transcriptomics (scNaST), a software suite to facilitate the analysis of spatial gene expression from second- and third-generation sequencing, allowing to generate a full-length near-single-cell transcriptional landscape of the tissue microenvironment.… read more here.

Keywords: full length; length spatial; single cell; spatial transcriptomics ... See more keywords

Single-nucleus transcriptomics reveals sepsis-related neurovascular dysfunction in the human hippocampus

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1648278

Abstract: Introduction Sepsis is increasingly recognized as a major precipitant of long-term cognitive impairment, yet the cellular mechanisms underlying hippocampal vulnerability remain elusive. Methods We performed single-nucleus RNA sequencing of human hippocampal tissues from sepsis and… read more here.

Keywords: hippocampus; astrocyte; transcriptomics reveals; nucleus transcriptomics ... See more keywords