Spatial Transcriptomics and snRNA-seq Expose CAF Niches Orchestrating Dual Stromal-Immune Barriers in Hepatocellular Carcinoma.
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DOI: 10.1002/advs.202514661
Abstract: Hepatocellular carcinoma (HCC) exhibits profound spatial heterogeneity driving therapeutic resistance, while the role of cancer‐associated fibroblasts (CAFs) in orchestrating immunosuppressive niches remains incompletely defined. This study integrates single‐nucleus RNA sequencing (snRNA‐seq) and spatial transcriptomics (stRNA‐seq)… read more here.
Keywords: snrna seq; spatial transcriptomics; hepatocellular carcinoma; cell ... See more keywords