Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201909999
Abstract: The effective treatment of Alzheimer's disease (AD) is hindered due to the hard blood–brain barrier (BBB) penetration and non‐selective distribution of drugs in the brain. Moreover, the complicated pathological mechanism of AD involves various pathway… read more here.
Keywords: transcytosis; lysosome escapable; escapable delivery; endo lysosome ... See more keywords
Protease Responsive Nanogels for Transcytosis across the Blood-Brain Barrier and Intracellular Delivery of Radiopharmaceuticals to Brain Tumor Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100812
Abstract: Despite profound advances in treatment approaches, gliomas remain associated with very poor prognoses. The residual cells after incomplete resection often migrate and proliferate giving a seed for highly resistant gliomas. The efficacy of chemotherapeutic drugs… read more here.
Keywords: blood brain; delivery; tumor cells; transcytosis ... See more keywords
Intracellular transcytosis of albumin in glomerular endothelial cells after endocytosis through caveolae
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25817
Abstract: We previously described albumin endocytosis through caveolae in human renal glomerular endothelial cells (HRGECs). This suggested a new albumin transcytosis pathway, in addition to the fenestral pathway. As a next step, we investigated albumin transcytosis… read more here.
Keywords: caveolae; glomerular endothelial; endocytosis; endothelial cells ... See more keywords
Quantifying Endothelial Transcytosis with Total Internal Reflection Fluorescence Microscopy (TIRF).
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-2051-9_7
Abstract: Apical-to-basal transcytosis by endothelial cells can be visualized and quantified using total internal reflection fluorescence (TIRF) microscopy of the basal membrane. Past techniques to study transcytosis including electron microscopy and transwells have several limitations such… read more here.
Keywords: transcytosis; internal reflection; endothelial transcytosis; microscopy ... See more keywords
Vitellogenin transcytosis in follicular cells of the honeybee Apis mellifera and the wasp Polistes simillimus
Sign Up to like & getrecommendations! Published in 2018 at "Protoplasma"
DOI: 10.1007/s00709-018-1260-y
Abstract: Vitellogenin receptor (VgR) is a low-density lipoprotein receptor responsible for the mediated endocytosis of vitellogenin (Vg) during egg formation in insects. The maturing oocyte is enveloped by a follicular epithelium, which has large intercellular spaces… read more here.
Keywords: insects; honeybee apis; apis mellifera; follicular cells ... See more keywords
Targeting blood-brain-barrier transcytosis – perspectives for drug delivery
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.08.025
Abstract: Efficient transcytosis across the blood-brain-barrier (BBB) is an important strategy for accessing drug targets within the central nervous system (CNS). Despite extensive research the number of studies reporting successful delivery of macromolecules or macromolecular complexes… read more here.
Keywords: transcytosis; blood brain; brain barrier;
Hydrophobicity Effects of γ-Glutamyl Transpeptidase-Responsive Polymers on the Catalytic Activity and Transcytosis Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00391
Abstract: Active transcytosis has recently sparked great interest in drug delivery as a novel route for tumor extravasation and infiltration. However, the rational design of transcytosis-inducing nanomedicines remains challenging. We recently demonstrated that the γ-glutamyl transpeptidase… read more here.
Keywords: ggt; glutamyl transpeptidase; transcytosis; activity transcytosis ... See more keywords
Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00768
Abstract: The presence of the blood–brain barrier (BBB) creates a nigh-on impenetrable obstacle for large macromolecular therapeutics that need to be delivered to the brain milieu to treat neurological disorders. To overcome this, one of the… read more here.
Keywords: bbb; transcytosis; cell bbb; brain ... See more keywords
Signature Effects of Vector-Guided Systemic Nano Bioconjugate Delivery Across Blood-Brain Barrier of Normal, Alzheimer’s, and Tumor Mouse Models
Sign Up to like & getrecommendations! Published in 2022 at "ACS Nano"
DOI: 10.1021/acsnano.1c10034
Abstract: The ability to cross the blood-brain barrier (BBB) is critical for targeted therapy of the central nerve system (CNS). Six peptide vectors were covalently attached to a 50 kDa poly(β-l-malic acid)-trileucine polymer forming P/LLL(40%)/vector conjugates.… read more here.
Keywords: blood brain; transcytosis; brain barrier; brain ... See more keywords
Transcytosis of Bacillus subtilis extracellular vesicles through an in vitro intestinal epithelial cell model
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60077-4
Abstract: Bacterial EVs have been related to inter-kingdom communication between probiotic/pathogenic bacteria and their hosts. Our aim was to investigate the transcytosis process of B. subtilis EVs using an in vitro intestinal epithelial cell model. In… read more here.
Keywords: epithelial cell; intestinal epithelial; cell model; vitro intestinal ... See more keywords
Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c7bm01012e
Abstract: Two major hurdles in nanomedicine are the limited strategies for synthesizing stealth nanoparticles and the poor efficacy of the nanoparticles in translocating across the blood brain barrier (BBB). Here we examined the uptake and transcytosis… read more here.
Keywords: blood brain; uptake transcytosis; model; brain barrier ... See more keywords