Pharmacological Perturbation of Mechanical Contractility Enables Robust Transdifferentiation of Human Fibroblasts into Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104682
Abstract: Direct cell reprogramming, also called transdifferentiation, is valuable for cell fate studies and regenerative medicine. Current approaches to transdifferentiation are usually achieved by directly targeting the nuclear functions, such as manipulating the lineage‐specific transcriptional factors,… read more here.
Keywords: cell; pharmacological perturbation; transdifferentiation; fibroblasts neurons ... See more keywords
HIPK2 role in the tumor–host interaction: Impact on fibroblasts transdifferentiation CAF‐like
Sign Up to like & getrecommendations! Published in 2019 at "Iubmb Life"
DOI: 10.1002/iub.2144
Abstract: The dialogue between cancer cells and the surrounding fibroblasts, tumor‐associated macrophages (TAM), and immune cells can create a tumor microenvironment (TME) able to promote tumor progression and metastasis and induce resistance to anticancer therapies. Cancer… read more here.
Keywords: host interaction; transdifferentiation; cancer cells; cancer ... See more keywords
Gelatin-based 3D conduits for transdifferentiation of mesenchymal stem cells into Schwann cell-like phenotypes.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.02.018
Abstract: In this study, gelatin-based 3D conduits with three different microstructures (nanofibrous, macroporous and ladder-like) were fabricated for the first time via combined molding and thermally induced phase separation (TIPS) technique for peripheral nerve regeneration. The… read more here.
Keywords: cell like; transdifferentiation; ladder like; cell ... See more keywords
mTOR Is Key to T Cell Transdifferentiation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell metabolism"
DOI: 10.1016/j.cmet.2019.01.008
Abstract: T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences… read more here.
Keywords: transdifferentiation; mtor key; key cell; cell ... See more keywords
Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) signalling is involved in transdifferentiation of hepatocyte-like cells
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.280
Abstract: The identification of key regulators in hepatic progenitor cells differentiation is determinant for organ regeneration and may improve stem cell transplantation for end-stage liver disease. Mesenchymal, embryonic and pluripotent stem cells have been investigated as… read more here.
Keywords: transdifferentiation; heparg; differentiation; hepatocyte ... See more keywords
The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson’ disease mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2022.577806
Abstract: Parkinson's disease (PD) is a chronic and progressive movement disorder caused by the selective loss of midbrain dopaminergic neurons of unknown etiology. Up to now, although there is a great development on treatments of PD,… read more here.
Keywords: transdifferentiation; neuroprotective effects; dopaminergic neurons; mice ... See more keywords
Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20057-1
Abstract: Recently, we reported that bacterial incorporation induces cellular transdifferentiation of human fibroblasts. However, the bacterium-intrinsic cellular- transdifferentiation factor remained unknown. Here, we found that cellular transdifferentiation is caused by ribosomes. Ribosomes, isolated from both prokaryotic… read more here.
Keywords: transdifferentiation; cellular transdifferentiation; incorporation somatic; ribosome incorporation ... See more keywords
Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40285
Abstract: Transdifferentiation has been described as a novel method for converting human fibroblasts into induced cardiomyocyte-like cells. Such an approach can produce differentiated cells to study physiology or pathophysiology, examine drug interactions or toxicities, and engineer… read more here.
Keywords: transcription; transdifferentiation; human fibroblasts; transdifferentiation human ... See more keywords
Molecular mechanisms of transcription factor mediated cell reprogramming: conversion of liver to pancreas
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200219
Abstract: Transdifferentiation is a type of cellular reprogramming involving the conversion of one differentiated cell type to another. This remarkable phenomenon holds enormous promise for the field of regenerative medicine. Over the last 20 years techniques… read more here.
Keywords: conversion; transcription; transdifferentiation; cell ... See more keywords
Interleukin-35 Enhances Regulatory T Cell Function by Potentially Suppressing Their Transdifferentiation into a T Helper 17-Like Phenotype in Kawasaki Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Immunological investigations"
DOI: 10.1080/08820139.2023.2201283
Abstract: Interleukin-35 (IL-35) modulates immune cell activity in inflammation and autoimmune disorders. However, its specific effects on regulatory T cells (Tregs) in Kawasaki disease remain ambiguous. We enrolled 37 patients with Kawasaki disease and 20 healthy… read more here.
Keywords: tregs; kawasaki disease; like phenotype; transdifferentiation ... See more keywords
Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP Workshop.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqad045
Abstract: OBJECTIVES Sessions 8 and 9 of the 2021 Society for Hematopathology and the European Association for Haematopathology Workshop aimed to collect examples of transdifferentiation, lineage infidelity, progression, and transformation in precursor and mature T/natural killer… read more here.
Keywords: cell; transdifferentiation; progression; cell neoplasms ... See more keywords