Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2073-0
Abstract: Malignant melanoma incidence has been increasing for over 30 years, and despite promising new therapies, metastatic disease remains difficult to treat. We describe preliminary results from a Phase I clinical trial (NCT01586403) of adoptive cell therapy… read more here.
Keywords: melanoma; reactive tcr; transduced cells; tcr transduced ... See more keywords
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function
Sign Up to like & getrecommendations! Published in 2017 at "Nature Protocols"
DOI: 10.1038/nprot.2017.083
Abstract: Retroviral (RV) expression of genes of interest (GOIs) is an invaluable tool and has formed the foundation of cellular engineering for adoptive cell therapy in cancer and other diseases. However, monitoring of transduced T cells… read more here.
Keywords: cells vivo; long term; cd8 cells; transduced cells ... See more keywords
Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-2055-4
Abstract: BackgroundMedulloblastoma (MB), the most common pediatric brain cancer, presents with a poor prognosis in a subset of patients with high risk disease, or at recurrence, where current therapies are ineffective. Cord blood (CB) natural killer… read more here.
Keywords: presence; medulloblastoma; transduced cells; dnrii ... See more keywords