Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Biosystems"
DOI: 10.1002/adbi.202000162
Abstract: Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging. However, in biological fluids, NPs interact with a wide range of proteins that form a coating known as protein corona.… read more here.
Keywords: plasma; gag binding; enhanced cellular; cellular transduction ... See more keywords
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202009382
Abstract: Amyloid-like peptide nanofibrils (PNFs) are abundant in nature providing rich bioactivities and playing both functional and pathological roles. The structural features responsible for their unique bioactivities are, however, still elusive. Supramolecular nanostructures are notoriously challenging… read more here.
Keywords: retroviral transduction; efficient retroviral; peptide nanofibrils; retroviral gene ... See more keywords
Tactile Chemomechanical Transduction Based on an Elastic Microstructured Array to Enhance the Sensitivity of Portable Biosensors.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced materials"
DOI: 10.1002/adma.201803883
Abstract: Tactile sensors capable of perceiving biophysical signals such as force, pressure, or strain have attracted extensive interest for versatile applications in electronic skin, noninvasive healthcare, and biomimetic prostheses. Despite these great achievements, they are still… read more here.
Keywords: chemomechanical transduction; tactile sensors; tactile chemomechanical; bio chemical ... See more keywords
Red Blood Cell Anchoring Enables Targeted Transduction and Re‐Administration of AAV‐Mediated Gene Therapy
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DOI: 10.1002/advs.202201293
Abstract: Adeno‐associated virus (AAV)‐mediated gene therapy is a promising therapeutic modality for curing many diseases including monogenic diseases. However, limited tissue‐targeting and restricted re‐administration due to the vector immunogenicity largely restrict its therapeutic potential. Here, using… read more here.
Keywords: aav mediated; administration; gene therapy; transduction ... See more keywords
Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno‐associated virus delivery in adult rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24183
Abstract: Recombinant adeno‐associated viral (AAV)‐mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to… read more here.
Keywords: cmv; expression; promoter; transduction ... See more keywords
Targeted Gene Therapy to Treat Disorders of the Central Nervous System
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders"
DOI: 10.1002/mds.29017
Abstract: Gene therapies to target disorders of the central nervous system (CNS) are an evolving field. Viral vectors, such as recombinant adeno-associated viruses (AAVs), are increasingly used because of their low pathogenicity and long-term transgene expression.… read more here.
Keywords: system; disorders central; central nervous; nervous system ... See more keywords
Effect of heart ischemia and administration route on biodistribution and transduction efficiency of AAV9 vectors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2974
Abstract: Adeno‐associated viruses (AAV) have become one of the most promising tools for gene transfer in clinics. Among all the serotypes, AAV9 has been described as the most efficient for cardiac transduction. In order to achieve… read more here.
Keywords: administration; aav9 vectors; heart; transduction efficiency ... See more keywords
Transduction of Human T Cell Subsets with Lentivirus.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1311-5_19
Abstract: Lentivirus-mediated gene transfer is an efficient method to introduce a variety of transgenes to human T cells. Here we describe a protocol to transduce human CD4+, CD8+, or CD4+ regulatory T cells. To illustrate the… read more here.
Keywords: cell subsets; regulatory cells; human cell; cell ... See more keywords
Delivery of Anti-IFNAR1 shRNA to Hepatic Cells Decreases IFNAR1 Gene Expression and Improves Adenoviral Transduction and Transgene Expression
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biotechnology"
DOI: 10.1007/s12033-021-00408-6
Abstract: Chronic liver injury leads to advanced fibrosis, cirrhosis, and hepatocellular carcinoma. Genetical cell treatment related to the use of adenovirus (Ads) has proven to be beneficial and efficient in the recovery of hepatic diseases. Nevertheless,… read more here.
Keywords: ifnar1; transgene expression; gene expression; expression ... See more keywords
TGFβ1 transduction enhances immunomodulatory capacity of neural stem cells in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.11.023
Abstract: Bone marrow-derived neural stem cells (BM-NSCs) have therapeutic effect on EAE, an animal model of multiple sclerosis. However, the beneficial effect is suboptimal due to the limited immunomodulatory capacity of these cells. In this study,… read more here.
Keywords: capacity; immunomodulatory capacity; tgf; stem cells ... See more keywords
Evolution and function of Tmc genes in mammalian hearing
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2020.06.011
Abstract: Auditory sensation in the mammalian inner ear requires mechanosensitive hair cells and an elaborate array of molecules that form the sensory transduction machinery. Several components of this machine have been identified, yet how the ensemble… read more here.
Keywords: evolution function; function tmc; function; tmc genes ... See more keywords