Effect of heart ischemia and administration route on biodistribution and transduction efficiency of AAV9 vectors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2974
Abstract: Adeno‐associated viruses (AAV) have become one of the most promising tools for gene transfer in clinics. Among all the serotypes, AAV9 has been described as the most efficient for cardiac transduction. In order to achieve… read more here.
Keywords: administration; aav9 vectors; heart; transduction efficiency ... See more keywords
Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120116
Abstract: AIMS Adenoviruses that have CNGRCVSGCAGRC peptide inserted into fiber (AdFNGR) or hexon (AdHNGR) protein, respectively, showed increased transduction of endothelial cells. In this study we investigated if cysteines within the CNGRCVSGCAGRC sequence inserted into Ad5… read more here.
Keywords: disulfide bonds; transduction efficiency; adfngr adhngr; ngr retargeted ... See more keywords
Higher Transduction Efficiency of AAV5 to Neural Stem Cells and Immature Neurons in Gerbil Dentate Gyrus Compared to AAV2 and rh10.
Sign Up to like & getrecommendations! Published in 2021 at "Human gene therapy"
DOI: 10.1089/hum.2021.106
Abstract: The safety and high efficiency of adeno-associated virus (AAV) vectors has facilitated their wide scale use to deliver therapeutic genes for experimental and clinical purposes in diseases affecting the central nervous system (CNS). AAV1, 2,… read more here.
Keywords: transduction efficiency; dentate gyrus; compared aav2; efficiency ... See more keywords
Transduction Efficiency of Adenovirus Vectors in Endothelial Cells and Vascular Smooth Muscle Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000821
Abstract: Adenoviral vectors are useful tools to manipulate a gene of interest in vitro and in vivo, including in the vascular system. The transduction efficiencies of adenoviral vectors in vascular cells such as endothelial cells (ECs)… read more here.
Keywords: efficiency; adenovirus; vsmcs; transduction efficiency ... See more keywords
Evaluation of Photoacoustic Transduction Efficiency of Candle Soot Nanocomposite Transmitters
Sign Up to like & getrecommendations! Published in 2018 at "IEEE Transactions on Nanotechnology"
DOI: 10.1109/tnano.2018.2845703
Abstract: Candle soot nanoparticles (CSNP) and polydimethyl-siloxane (PDMS) composite has shown the highly efficient photoacoustic transduction owing to their high light absorption coefficient and low interfacial thermal resistance. In this study, we report the effect of… read more here.
Keywords: candle soot; photoacoustic transduction; transduction efficiency;
Transduction efficiency and vector biodistribution following prenatal vs neonatal AAV5 gene therapy for Hemophilia A in a sheep model
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-4316
Abstract: Hemophilia A (HA) patients treated with AAV-based gene therapy (GT) receive vector serotypes that preclinical studies indicated to be hepatotropic. However, the limited clinical biodistribution data available from the single FDA-approved AAV GT product have… read more here.
Keywords: vector; prenatal neonatal; transduction efficiency; nngt recipients ... See more keywords
An automated platform for lentiviral transduction for HSC gene therapy promotes fitness of hematopoietic stem cells combined with higher transduction efficiency
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-7837
Abstract: Although therapies for HSC gene therapy have been recently approved (Zynteglo™, Lyfgenia™ and Casgevy®), still certain challenges remain associated with high costs, scalability and safety related to leukemic events. These indicate a need for improved… read more here.
Keywords: transduction; transduction efficiency; clinimacs prodigy; automated platform ... See more keywords
A Tumor-targeting Adenovirus with High Gene-transduction Efficiency for Primary Pancreatic Cancer and Ascites Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11730
Abstract: BACKGROUND Optimizing targeting strategies for vectors in order to enhance antitumor activity and secure patient safety is important for cancer gene therapy. We previously identified two pancreatic cancer-targeting ligands (PFWSGAV: PFW and SYENFSA: SYE) by… read more here.
Keywords: cancer; gene; transduction efficiency; pancreatic cancer ... See more keywords
Evaluating the transduction efficiency of systemically delivered AAV vectors in the rat nervous system
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1001007
Abstract: Gene delivery or manipulation with viral vectors is a frequently used tool in basic neuroscience studies. Adeno-associated viruses (AAV) are the most widely used vectors due to their relative safety and long-term efficacy without causing… read more here.
Keywords: efficient transducing; evaluating transduction; aav retro; transduction ... See more keywords
Chimeric Mice Engrafted With Canine Hepatocytes Exhibits Similar AAV Transduction Efficiency to Hemophilia B Dog
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.815317
Abstract: Adeno-associated virus (AAV) mediated gene therapy has been successfully applied in clinical trials, including hemophilia. Novel AAV vectors have been developed with enhanced transduction and specific tissue tropism. Considering the difference in efficacy of AAV… read more here.
Keywords: aav transduction; transduction; mice; canine hepatocytes ... See more keywords
Gene Therapy in the Light of Lifestyle Diseases: Budesonide, Acetaminophen and Simvastatin Modulates rAAV Transduction Efficiency
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceuticals"
DOI: 10.3390/ph17091213
Abstract: Recombinant AAV (rAAV) vectors are increasingly favored for gene therapy due to their useful features of vectorology, such as transfection of dividing and nondividing cells, the presence of tissue-specific serotypes, and biosafety considerations. This study… read more here.
Keywords: transduction; raav transduction; transduction efficiency; gene therapy ... See more keywords