Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.07.029
Abstract: In vitro generated dendritic cells (DCs) have been studied in cancer immunotherapy for decades. However, the detailed molecular mechanism underlying transendothelial migration (TEM) of DC vaccine across the endothelial barrier to regional lymph nodes (LNs)… read more here.
Keywords: transendothelial migration; jaml; cancer immunotherapy; cancer ... See more keywords
High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0333-4
Abstract: Cancer is a major cause of death in children worldwide, with B-lineage cell acute lymphoblastic leukemia (B-ALL) being the most frequent childhood malignancy. Relapse, treatment failure and organ infiltration worsen the prognosis, warranting a better… read more here.
Keywords: transendothelial migration; cortactin expression; cortactin; leukemia ... See more keywords
In vivo Imaging Reveals Unique Neutrophil Transendothelial Migration Patterns in Inflamed Intestines
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0069-5
Abstract: Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of gastrointestinal inflammation, with significant implications for host defense, injury and repair. However, phenotypic and mechanistic aspects of PMN recruitment in inflamed intestines have not… read more here.
Keywords: transendothelial migration; vivo imaging; imaging reveals; inflamed intestines ... See more keywords
PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29930-0
Abstract: Programmed death-1 (PD-1) and its ligand PD-L1 are checkpoint molecules which regulate immune responses. Little is known about their functions in T cell migration and there are contradictory data about their roles in regulatory T… read more here.
Keywords: regulates cell; selectively regulates; transendothelial migration; signaling selectively ... See more keywords
Ionizing radiation increases the endothelial permeability and the transendothelial migration of tumor cells through ADAM10-activation and subsequent degradation of VE-cadherin
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6219-7
Abstract: BackgroundWe analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of endothelial intercellular junctions, and… read more here.
Keywords: transendothelial migration; degradation; tumor cells; permeability ... See more keywords
Elucidating the Biomechanics of Leukocyte Transendothelial Migration by Quantitative Imaging
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.635263
Abstract: Leukocyte transendothelial migration is crucial for innate immunity and inflammation. Upon tissue damage or infection, leukocytes exit blood vessels by adhering to and probing vascular endothelial cells (VECs), breaching endothelial cell-cell junctions, and transmigrating across… read more here.
Keywords: leukocyte transendothelial; transendothelial migration; elucidating biomechanics; biomechanics ... See more keywords
Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02227
Abstract: The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process. Human CD14+ inflammatory monocytes express… read more here.
Keywords: transendothelial migration; erm binding; protrusion; tem ... See more keywords
Defective Neutrophil Transendothelial Migration and Lateral Motility in ARPC1B Deficiency Under Flow Conditions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.678030
Abstract: The actin-related protein (ARP) 2/3 complex, essential for organizing and nucleating branched actin filaments, is required for several cellular immune processes, including cell migration and granule exocytosis. Recently, genetic defects in ARPC1B, a subunit of… read more here.
Keywords: transendothelial migration; defective neutrophil; migration; neutrophil transendothelial ... See more keywords
Fucoxanthin prevents breast cancer metastasis by interrupting circulating tumor cells adhesion and transendothelial migration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.960375
Abstract: Metastasis is the leading cause of cancer-related death and a critical challenge in improving cancer treatment today. Circulating tumor cells (CTCs) adhesion to and across the vascular endothelium are critical steps in the establishment of… read more here.
Keywords: adhesion; transendothelial migration; cancer; cancer metastasis ... See more keywords