Conformational Dynamics of an α-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10854
Abstract: Many amyloid fibrils associated with neurodegenerative diseases consist of an ordered fibril core (FC) and disordered terminal regions (TRs). The former represents a stable scaffold, while the latter is rather active in binding with various… read more here.
Keywords: insensitive nuclei; microscopy; transfer based; nuclei enhanced ... See more keywords
Bioluminescence resonance energy transfer-based biosensors allow monitoring of ligand- and transducer-mediated GPCR conformational changes
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0101-z
Abstract: G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that mediate a variety of cellular response which make them a target of choice for drug development in many indications. It is now well established that GPCRs can… read more here.
Keywords: energy transfer; monitoring ligand; biology; resonance energy ... See more keywords
Feature transfer based adversarial domain adaptation method for cross-domain road extraction
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DOI: 10.1080/10106049.2020.1753819
Abstract: In order to improve the cross-domain applicability of road segmentation, a feature transfer based adversarial domain adaptation method is presented for cross-domain road extraction. The presented m... read more here.
Keywords: cross domain; road; domain; feature transfer ... See more keywords
A Bipartite Network and Resource Transfer-Based Approach to Infer lncRNA-Environmental Factor Associations
Sign Up to like & getrecommendations! Published in 2018 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2017.2695187
Abstract: Phenotypes and diseases are often determined by the complex interactions between genetic factors and environmental factors (EFs). However, compared with protein-coding genes and microRNAs, there is a paucity of computational methods for understanding the associations… read more here.
Keywords: bipartite network; network resource; resource transfer; approach ... See more keywords
DeepPoison: Feature Transfer Based Stealthy Poisoning Attack for DNNs
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Circuits and Systems II: Express Briefs"
DOI: 10.1109/tcsii.2021.3060896
Abstract: Deep neural networks are susceptible to poisoning attacks by purposely polluted training data with specific triggers. As existing episodes mainly focused on attack success rate with patch-based samples, defense algorithms can easily detect these poisoning… read more here.
Keywords: deeppoison; transfer based; feature transfer; deeppoison feature ... See more keywords