Sulfur Pentafluoride is a Preferred Reagent Cation for Negative Electron Transfer Dissociation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The American Society for Mass Spectrometry"
DOI: 10.1007/s13361-017-1600-8
Abstract: AbstractNegative mode proteome analysis offers access to unique portions of the proteome and several acidic post-translational modifications; however, traditional collision-based fragmentation methods fail to reliably provide sequence information for peptide anions. Negative electron transfer dissociation… read more here.
Keywords: reagent cation; cation; transfer dissociation; electron transfer ... See more keywords
Negative Polarity Helium Charge Transfer Dissociation Tandem Mass Spectrometry: Radical-Initiated Fragmentation of Complex Polysulfated Anions.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b00473
Abstract: This work provides the first use of helium charge transfer dissociation (He-CTD) tandem mass spectrometry (MS/MS) in negative polarity mode. Three sulfated oligosaccharides of natural origin were chosen as representative structures that are difficult to… read more here.
Keywords: dissociation; mass; negative polarity; transfer dissociation ... See more keywords
Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b02194
Abstract: Antibody-drug conjugates (ADCs) are designed to combine the target specificity of monoclonal antibodies and potent cytotoxin drugs to achieve better therapeutic outcome. Comprehensive evaluation of the quality attributes of ADCs is critical for drug development… read more here.
Keywords: drug conjugates; transfer dissociation; analysis; electron transfer ... See more keywords
Structural Characterization of Natural and Synthetic Macrocycles Using Charge-Transfer Dissociation Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Society for Mass Spectrometry"
DOI: 10.1021/jasms.1c00369
Abstract: Research in natural products (NPs) has gained interest as drug developers turn to nature to combat problems with drug resistance, drug delivery, and emerging diseases. Whereas NPs offer a tantalizing source of new pharmacologically active… read more here.
Keywords: dissociation; characterization natural; transfer dissociation; charge transfer ... See more keywords
Structural characterization of human milk oligosaccharides (HMOs) using ultra-high performance liquid chromatography-helium charge transfer dissociation mass spectrometry (UHPLC-he-CTD-MS).
Sign Up to like & getrecommendations! Published in 2022 at "Glycobiology"
DOI: 10.1093/glycob/cwac010
Abstract: The combination of helium charge transfer dissociation mass spectrometry (He-CTD-MS) with ultra-high performance liquid chromatography (UHPLC) is presented for the analysis of a complex mixture of acidic and neutral human milk oligosaccharides (HMOs). The research… read more here.
Keywords: dissociation; transfer dissociation; dissociation mass; charge transfer ... See more keywords